Kaur Harpreet, Krishna Deepika, Shetty Nivedita, Krishnan Sandhya, Srinivas M S, Rao Kamini A
Consultant Reproductive Medicine, Bangalore Assisted Conception Centre, Bangalore, India.
J Reprod Infertil. 2012 Oct;13(4):225-31.
The purpose of present study was to evaluate the role of pre-ovulatory GnRH agonist therapy on IVF outcomes in GnRH antagonist cycles.
In this prospective study we recruited 100 infertile women undergoing IVF cycles with GnRH antagonists. The patients were assigned to two groups: Group A (the study group, n = 42) were assigned for receiving hCG + triptorelin for the final oocyte maturation and group B (the control group, n = 58) were assigned for only hCG. The t-test, chi-square (χ(2)), and Fisher's exact test were used for data analysis. A p < 0.05 was taken as statistically significant. The results are presented by mean± SD, and in percents (%).
LH levels significantly (p < 0.001) increased in the study group on the day of oocyte retrieval. All embryological parameters including the number of mature oocytes, fertilization and cleavage rates, number of high quality embryos and number of cases whose embryos were frozen were non-significantly higher in the study group. There were small but non-significant improvements in the clinical pregnancy, ongoing pregnancy, live birth and implantation rates in the study group.
Administering a single dose of GnRH agonist before oocyte retrieval in antagonist cycles may be helpful in improving the pregnancy rate but the results need to be verified in a larger trials.
本研究的目的是评估排卵前GnRH激动剂治疗在GnRH拮抗剂周期体外受精结局中的作用。
在这项前瞻性研究中，我们招募了100名接受GnRH拮抗剂体外受精周期的不孕妇女。患者被分为两组：A组（研究组，n = 42）接受hCG +曲普瑞林用于最终卵母细胞成熟，B组（对照组，n = 58）仅接受hCG。采用t检验、卡方（χ(2)）检验和Fisher精确检验进行数据分析。p < 0.05被视为具有统计学意义。结果以均数±标准差和百分比（%）表示。
研究组在取卵日LH水平显著升高（p < 0.001）。包括成熟卵母细胞数量、受精率和卵裂率、优质胚胎数量以及胚胎冷冻病例数在内的所有胚胎学参数，研究组均略高但无显著差异。研究组的临床妊娠率、持续妊娠率、活产率和着床率有小幅但不显著的提高。
在拮抗剂周期取卵前给予单剂量GnRH激动剂可能有助于提高妊娠率，但结果需要在更大规模的试验中得到验证。
