Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.
Wound Repair Regen. 2013 Sep-Oct;21(5):740-5. doi: 10.1111/wrr.12079. Epub 2013 Aug 8.
The purpose of this study was to compare two negative-pressure wound healing systems (NPWT), -75 mmHg with a silicone-coated (SC) dressing and -125 mmHg with polyurethane foam dressing (standard of care). In addition, this study compared the effects of two different dressing interfaces, SC dressing and gauze, with -75 mmHg pressure. For both comparisons, two groups of five pigs were evaluated over a 21-day time course. Two excisional wounds were made on each animal and NPWT dressings were applied. A canvas saddle was constructed to hold the NPWT device so the animal had free range of the pen. Dressings were changed twice a week and wound measurements were taken. Specimens for histology and gene expression analyses were taken on day 7 and 21. These data show that there is increased expression in a few genes associated with remodeling and inflammatory processes in the NPWT-125 with polyurethane foam as compared with the NPWT-75 with SC dressing. These two systems, however, are equivalent with respect to wound healing, histology, and gene expression over 21 days of healing. Further, we demonstrate that there is no difference in measure of healing between the SC dressing and a basic gauze dressing.
本研究旨在比较两种负压伤口愈合系统（NPWT）：-75mmHg 与硅酮涂层（SC）敷料和-125mmHg 与聚氨酯泡沫敷料（标准护理）。此外，本研究还比较了两种不同的敷料界面，-75mmHg 压力下的 SC 敷料和纱布，对治疗效果的影响。在 21 天的时间内，对两组各五头猪进行了比较。在每只动物身上做了两个切除伤口，并应用 NPWT 敷料。用马毯制作了一个马鞍，以固定 NPWT 设备，使动物在围栏中可以自由活动。每周更换两次敷料，并测量伤口。在第 7 天和第 21 天取标本进行组织学和基因表达分析。与 NPWT-75 与 SC 敷料相比，NPWT-125 与聚氨酯泡沫敷料中与重塑和炎症过程相关的少数基因表达增加。然而，这两种系统在 21 天的愈合过程中，在伤口愈合、组织学和基因表达方面是等效的。此外，我们还证明了 SC 敷料和基本纱布敷料在愈合测量方面没有差异。
