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经几何校正的相控阵经胸廓高强度聚焦超声治疗。

Transcostal high-intensity focused ultrasound treatment using phased array with geometric correction.

机构信息

Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.

出版信息

J Acoust Soc Am. 2013 Aug;134(2):1503-14. doi: 10.1121/1.4812869.

Abstract

In the high-intensity focused ultrasound treatment of liver tumors, ultrasound propagation is affected by the rib cage. Because of the diffraction and absorption of the bone, the sound distribution at the focal plane is altered, and more importantly, overheating on the rib surface might occur. To overcome these problems, a geometric correction method is applied to turn off the elements blocked by the ribs. The potential of steering the focus of the phased-array along the propagation direction to improve the transcostal treatment was investigated by simulations and experiments using different rib models and transducers. The ultrasound propagation through the ribs was computed by a hybrid method including the Rayleigh-Sommerfeld integral, k-space method, and angular spectrum method. A modified correction method was proposed to adjust the output of elements based on their relative area in the projected "shadow" of the ribs. The simulation results showed that an increase in the specific absorption rate gain up to 300% was obtained by varying the focal length although the optimal value varied in each situation. Therefore, acoustic simulation is required for each clinical case to determine a satisfactory treatment plan.

摘要

在高强度聚焦超声治疗肝脏肿瘤时,超声传播会受到肋骨的影响。由于骨骼的衍射和吸收,焦平面上的声分布会发生改变,更重要的是,肋骨表面可能会过热。为了克服这些问题,应用几何校正方法来关闭被肋骨阻挡的元件。通过使用不同的肋骨模型和换能器进行模拟和实验,研究了沿传播方向引导相控阵焦点以改善经肋骨治疗的可能性。通过包括瑞利-索末菲积分、k 空间方法和角谱方法在内的混合方法计算了通过肋骨的超声传播。提出了一种改进的校正方法,根据元件在肋骨的投影“阴影”中的相对面积来调整元件的输出。虽然在每种情况下最佳值都不同,但模拟结果表明,通过改变焦距可以获得高达 300%的比吸收率增益。因此,需要对每个临床病例进行声学模拟,以确定满意的治疗计划。

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