Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University, 1 Medical College Road, Chongqing 400016, People's Republic of China.
J Acoust Soc Am. 2013 Aug;134(2):1695-701. doi: 10.1121/1.4812893.
The ideal cancer therapy not only induces the death of all localized tumor cells without damage to surrounding normal tissue, but also activates a systemic antitumor immunity. High intensity focused ultrasound (HIFU) has the potential to be such a treatment, as it can non-invasively ablate a targeted tumor below the skin surface, and may subsequently augment host antitumor immunity. This paper is to review increasing pre-clinical and clinical evidence linking antitumor immune response to HIFU ablation, and to discuss the potential mechanisms involved in HIFU-enhanced host antitumor immunity. The seminal studies performed so far indicate that although it is not possible to conclude definitively on the connection between HIFU treatment and antitumor immune response, it is nonetheless important to conduct extensive studies on the subject in order to elucidate the processes involved.
理想的癌症疗法不仅能诱导所有局部肿瘤细胞死亡而不损伤周围正常组织，还能激活全身性抗肿瘤免疫。高强度聚焦超声（HIFU）有潜力成为这样一种治疗方法，因为它可以无创地消融皮肤表面以下的靶向肿瘤，并且随后可能增强宿主抗肿瘤免疫。本文旨在综述越来越多的将抗肿瘤免疫反应与 HIFU 消融联系起来的临床前和临床证据，并讨论 HIFU 增强宿主抗肿瘤免疫的潜在机制。迄今为止进行的开创性研究表明，虽然不能确定 HIFU 治疗与抗肿瘤免疫反应之间的联系，但仍有必要对此进行广泛研究，以阐明所涉及的过程。
