Wu Feng
Nuffield Department of Surgical Sciences, HIFU Unit, Churchill Hospital, University of Oxford, Oxford, OX3 9 DU, UK.
Institute of Ultrasonic Engineering in Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China.
Adv Exp Med Biol. 2016;880:131-53. doi: 10.1007/978-3-319-22536-4_8.
The ideal cancer therapy not only induces the death of all localized tumor cells with less damage to surrounding normal tissue, but also activates a systemic antitumor immunity. Heat-based tumor ablation has the potential to be such a treatment as it can minimal-invasively ablate a targeted tumor below the skin surface, and may subsequently augment host antitumor immunity. This chapter primarily introduces increasing pre-clinical and clinical evidence linking antitumor immune response to thermal tumor ablation, and then discusses the potential mechanisms involved in ablation-enhanced host antitumor immunity. The seminal studies performed so far indicate that although it is not possible to make definite conclusions on the connection between thermal ablation and antitumor immune response, it is nonetheless important to conduct extensive studies on the subject in order to elucidate the processes involved.
理想的癌症治疗不仅要诱导所有局部肿瘤细胞死亡，同时对周围正常组织的损伤要最小，还要激活全身抗肿瘤免疫。基于热的肿瘤消融有潜力成为这样一种治疗方法，因为它可以以微创方式消融皮肤表面以下的靶向肿瘤，并且随后可能增强宿主抗肿瘤免疫力。本章主要介绍越来越多的临床前和临床证据，这些证据将抗肿瘤免疫反应与热肿瘤消融联系起来，然后讨论消融增强宿主抗肿瘤免疫力所涉及的潜在机制。迄今为止进行的开创性研究表明，虽然目前还无法就热消融与抗肿瘤免疫反应之间的联系得出明确结论，但对该主题进行广泛研究以阐明其中涉及的过程仍然很重要。
