Program in Cancer Research, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.
Blood Cells Mol Dis. 2013 Dec;51(4):264-70. doi: 10.1016/j.bcmd.2013.07.005. Epub 2013 Aug 6.
Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels.
造血干细胞（HSC）位于成年哺乳动物的骨髓中，为生物体的整个生命周期维持造血功能，它们在胚胎发育过程中被特化和产生。我们才刚刚开始了解 HSC 如何从更原始的细胞发育而来，以及涉及的信号通路的复杂性。在这项工作中，我们回顾了两个关键途径 Notch 和 Wnt 在 HSC 及其初生微环境（动脉血管）的特化和发育中的作用。
