Yang Jigang, Kan Ying, Ge Benjamin H, Yuan Leilei, Li Chunlin, Zhao Wenrui
Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, PR China.
Acta Radiol. 2014 May;55(4):389-98. doi: 10.1177/0284185113496679. Epub 2013 Aug 8.
Gallium-68 somatostatin receptor positron emission tomography (PET) has been used in the diagnosis of neuroendocrine tumors (NETs). The compounds often used in molecular imaging of NETs with PET are 68Ga-DOTATOC, 68Ga-DOTATATE, and 68Ga-DOTANOC. There is varying affinity to different somatostatin receptors.
To systematically review and perform a meta-analysis of published data regarding the diagnostic role of 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs.
A comprehensive literature search of studies published through 30 April 2013 regarding 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs was performed using the PubMed/MEDLINE, Embase, and Scopus databases. Pooled sensitivity and specificity of 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs were calculated. The area under the receiver-operating characteristic (ROC) curve was calculated to measure the accuracy of 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs.
Ten studies comprising 416 patients with NETs were included in this meta-analysis. The pooled sensitivity of 68Ga-DOTATOC and 68Ga-DOTATATE PET in the diagnosis of NETs calculated on a per-patient-based analysis was 93% (95% confidence interval [CI] 89-96%) and 96% (95% CI 91-99%). The pooled specificity of 68Ga-DOTATOC and 68Ga-DOTATATE PET in diagnosing NETs was 85% (95% CI 74-93%) and 100% (95% CI 82-100%). The area under the ROC curve of 68Ga-DOTATOC and 68Ga-DOTATATE PET was 0.96 and 0.98, respectively, on a per-patient-based analysis.
The molecular imaging agents 68Ga-DOTATOC and 68Ga-DOTATATE demonstrated high sensitivity and specificity in the diagnosis of NETs on PET scan. Although both are accurate tools in the diagnosis of NETs, 68Ga-DOTATATE PET may be more sensitive and specific than 68Ga-DOTATOC PET scan.
镓-68生长抑素受体正电子发射断层扫描（PET）已用于神经内分泌肿瘤（NETs）的诊断。PET用于NETs分子成像的常用化合物有68Ga-DOTATOC、68Ga-DOTATATE和68Ga-DOTANOC。它们对不同生长抑素受体的亲和力各不相同。
系统评价并对已发表的关于68Ga-DOTATOC和68Ga-DOTATATE PET在NETs诊断中作用的数据进行荟萃分析。
使用PubMed/MEDLINE、Embase和Scopus数据库，对截至2013年4月30日发表的有关68Ga-DOTATOC和68Ga-DOTATATE PET在NETs诊断中的研究进行全面文献检索。计算68Ga-DOTATOC和68Ga-DOTATATE PET在NETs诊断中的合并敏感性和特异性。计算受试者操作特征（ROC）曲线下面积，以衡量68Ga-DOTATOC和68Ga-DOTATATE PET在NETs诊断中的准确性。
本荟萃分析纳入了10项研究，共416例NETs患者。基于患者个体分析计算得出，68Ga-DOTATOC和68Ga-DOTATATE PET在NETs诊断中的合并敏感性分别为93%（95%置信区间[CI]89-96%）和96%（95%CI 91-99%）。68Ga-DOTATOC和68Ga-DOTATATE PET在诊断NETs中的合并特异性分别为85%（95%CI 74-93%）和100%（95%CI 82-100%）。基于患者个体分析，68Ga-DOTATOC和68Ga-DOTATATE PET的ROC曲线下面积分别为0.96和0.98。
分子成像剂68Ga-DOTATOC和68Ga-DOTATATE在PET扫描诊断NETs中显示出高敏感性和特异性。虽然两者都是诊断NETs的准确工具，但68Ga-DOTATATE PET可能比68Ga-DOTATOC PET扫描更敏感和特异。
