Department of Forest Sciences, P.O. Box 27, Latokartanonkaari 7, 00014 University of Helsinki, Helsinki, Finland.
Mycologia. 2013 Nov-Dec;105(6):1471-8. doi: 10.3852/13-077. Epub 2013 Aug 8.
Hydrophobins are small, secreted proteins playing important roles at different stages of fungal life cycles. Their characteristic feature is the presence of eight highly conserved cysteine residues. Here we present an inventory and evolutionary analysis of hydrophobin genes from three wood-degrading basidiomycetes, Phlebia brevispora, Ganoderma sp. and Bjerkandera adusta. The genomes of the three analyzed species are characterized by the presence of high copy numbers of hydrophobin genes. Results of the phylogenetic analysis of the identified proteins revealed that many of them share a high degree of sequence similarity and probably originated from a series of duplication events. The presence of several clusters of adjacent copies of the hydrophobin gene in a particular location in the genome further supports the interpretation that gene duplication has played a role in the evolution of hydrophobins in the analyzed species.
疏水蛋白是在真菌生命周期的不同阶段发挥重要作用的小分泌蛋白。它们的特征是存在 8 个高度保守的半胱氨酸残基。在这里，我们展示了三种木质素降解担子菌，短密青霉、灵芝和粗糙侧耳，的疏水蛋白基因的目录和进化分析。三种分析物种的基因组的特点是存在大量的疏水蛋白基因的高拷贝数。鉴定出的蛋白质的系统发育分析结果表明，它们中的许多具有高度的序列相似性，可能起源于一系列重复事件。在基因组的特定位置存在几个相邻的疏水蛋白基因簇进一步支持了这样的解释，即基因复制在分析物种中疏水蛋白的进化中发挥了作用。
