Cao Qinghua, Li Yang, Lin Hanliang, Ke Zunfu, Liu Yongdong, Ye Ziyin
Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Am J Dermatopathol. 2013 Dec;35(8):851-5. doi: 10.1097/DAD.0b013e31828de73a.
Mantle cell lymphoma (MCL) is a type of aggressive mature B-cell neoplasm. Skin involvement of MCL is extremely rare, with only 21 cases reported so far. We report a case of MCL with blastoid variant, presenting as skin lesion initially. A 53-year-old man presented with increasing petechiae and ecchymosis after slight hit. Biopsy of skin showed tumor cells densely infiltrated dermal and subcutis with blastoid cytological features and numerous mitotic figures. Immunohistochemistry study showed tumor cells were positive for CD20, CD79a, BCL2, CyclinD1, and MUM1 but lost CD5 expression. Fluorescence in situ hybridization (FISH) studies demonstrated t(11;14). Although received chemotherapy after the diagnosis established, the patient deteriorated rapidly and died 5 weeks after presenting with skin lesions.
套细胞淋巴瘤（MCL）是一种侵袭性成熟B细胞肿瘤。MCL累及皮肤极为罕见，迄今为止仅报告过21例。我们报告1例伴有母细胞样变异型的MCL，最初表现为皮肤病变。一名53岁男性在轻微碰撞后出现瘀点和瘀斑增多。皮肤活检显示肿瘤细胞密集浸润真皮和皮下组织，具有母细胞样细胞学特征和大量有丝分裂象。免疫组织化学研究显示肿瘤细胞CD20、CD79a、BCL2、细胞周期蛋白D1和MUM1呈阳性，但CD5表达缺失。荧光原位杂交（FISH）研究显示t（11；14）。尽管在确诊后接受了化疗，但患者病情迅速恶化，在出现皮肤病变5周后死亡。
