Ugrinska A, Miladinova D, Trajkovska M, Zdravkovska M, Kuzmanovska S, Tripunoski T, Vaskova O
Academician Isak S Tadzer Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, UKIM, Skopje, R. Macedonia.
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2013;34(1):115-9.
Leptin is an adipocytokine that has an important role in energy homeostasis and therefore in the patho-physiology of obesity. Leptin levels are influenced by many factors such as gender, race, energy intake, fat mass, etc. The aim of our study is to investigate the relationship of circulating leptin levels to anthropometric parameters and to the subcutaneous and visceral fat tissue determined by ultrasonography in healthy overweight and obese women. The study included 50 healthy women, with body mass index (BMI) above 25 kg/m2. Measurements of anthropometric parameters were performed with a standardized technique. The subcutaneous and visceral fat tissue was measured with ultrasound 1 cm above the umbilicus. Leptin was determined by radioimmunoassay. The serum leptin levels presented a positive correlation between the levels of leptin and BMI (r-0.73, p<0.05) waist circumference (r-0.73, p<0.05) hip circumference (r-0.74, p<0.05), thigh circumference (r-0.56, p<0.05) and abdominal subcutaneous fat tissue (r- 0.46, p<0.05). There was no correlation between leptin and visceral fat tissue, waist to hip and waist to thigh ratio. The results of our study confirmed the correlation between leptin and BMI. The correlation between leptin and all measured circumferences cannot be attributed to a particular fat depot, but rather reflect the correlation between this adipocytokine and the total body fat. The subcutaneous fat depot determined by ultrasound showed a correlation with leptin, while this kind of connection was not established for the visceral fat tissue.
瘦素是一种脂肪细胞因子，在能量平衡中发挥重要作用，因而在肥胖的病理生理学中也起着重要作用。瘦素水平受多种因素影响，如性别、种族、能量摄入、脂肪量等。我们研究的目的是调查健康超重和肥胖女性中循环瘦素水平与人体测量参数以及超声测定的皮下和内脏脂肪组织之间的关系。该研究纳入了50名体重指数（BMI）高于25kg/m²的健康女性。人体测量参数采用标准化技术进行测量。在脐上1厘米处用超声测量皮下和内脏脂肪组织。瘦素通过放射免疫测定法测定。血清瘦素水平显示瘦素水平与BMI（r = 0.73，p<0.05）、腰围（r = 0.73，p<0.05）、臀围（r = 0.74，p<0.05）、大腿围（r = 0.56，p<0.05）和腹部皮下脂肪组织（r = 0.46，p<0.05）之间呈正相关。瘦素与内脏脂肪组织、腰臀比和腰大腿比之间无相关性。我们的研究结果证实了瘦素与BMI之间的相关性。瘦素与所有测量周长之间的相关性不能归因于特定的脂肪储存部位，而是反映了这种脂肪细胞因子与全身脂肪之间的相关性。超声测定的皮下脂肪储存部位与瘦素显示出相关性，而内脏脂肪组织未建立这种联系。
