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角支撑型人工晶状体植入术中地塞米松玻璃体内植入物(Ozurdex®)的巩膜固定术

Scleral fixation of dexamethasone intravitreal implant (OZURDEX®) in a case of angle-supported lens implantation.

作者信息

Mateo Carlos, Alkabes Micol, Burés-Jelstrup Anniken

机构信息

IMO-Instituto de Microcirugía Ocular, Barcelona, Spain.

出版信息

Int Ophthalmol. 2014 Jun;34(3):661-5. doi: 10.1007/s10792-013-9841-4. Epub 2013 Aug 9.

DOI:10.1007/s10792-013-9841-4
PMID:23928945
Abstract

OZURDEX(®) is a biodegradable drug delivery system which has been reported to be an effective treatment in cases of macular edema. However, migration of the implant into the anterior chamber with elevation of intraocular pressure and corneal decompensation might occur in some cases. We report a case of an 80-year-old male who underwent intravitreal scleral fixation of OZURDEX(®) due to postoperative macular edema secondary to complicated cataract surgery. He had a previous angle-supported lens implantation with superior Nd:YAG laser iridotomy. During surgery, the dexamethasone implant was introduced into the vitreous cavity and sutured to the sclera using a 10-0 non-absorbable polypropylene suture to prevent the risk of anterior complications in case of migration into the anterior chamber. After 6 months of follow-up, the macular edema had disappeared completely, the drug delivery system was not observed in the posterior segment and best-corrected visual acuity improved from 20/125 to 20/40 (Snellen equivalent). Neither anterior nor posterior segment complications were reported during the follow-up period. Intravitreal scleral fixation of the OZURDEX(®) to the pars plana could be recommended as an alternative technique to avoid anterior migration of the device in a patient with an anterior chamber intraocular lens, which may lead to corneal decompensation and increased intraocular pressure.

摘要

Ozurdex(®)是一种可生物降解的药物递送系统,据报道在黄斑水肿病例中是一种有效的治疗方法。然而,在某些情况下,植入物可能会迁移到前房,导致眼压升高和角膜失代偿。我们报告了一例80岁男性患者,因复杂白内障手术后的黄斑水肿接受了Ozurdex(®)的玻璃体巩膜固定术。他曾接受过前房支撑人工晶状体植入术并进行了Nd:YAG激光周边虹膜切开术。手术过程中,将地塞米松植入物引入玻璃体腔,并用10-0不可吸收聚丙烯缝线缝合至巩膜,以防止植入物迁移至前房时发生前部并发症。经过6个月的随访,黄斑水肿完全消失,在后段未观察到药物递送系统,最佳矫正视力从20/125提高到20/40(Snellen等效值)。随访期间未报告任何前部或后部并发症。对于植入前房人工晶状体的患者,Ozurdex(®)的玻璃体巩膜固定术可作为一种替代技术推荐,以避免该装置向前迁移,因为这可能导致角膜失代偿和眼压升高。

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