两种不同前列腺素F2α酯的眼部效应。一项针对正常眼压眼睛的双盲交叉研究。

Ocular effects of two different prostaglandin F2 alpha esters. A doublemasked cross-over study on normotensive eyes.

作者信息

Villumsen J, Alm A

机构信息

Department of Ophthalmology, University Hospital, Umeå, Sweden.

出版信息

Acta Ophthalmol (Copenh). 1990 Jun;68(3):341-3. doi: 10.1111/j.1755-3768.1990.tb01935.x.

DOI:10.1111/j.1755-3768.1990.tb01935.x

PMID:2392914

Abstract

Ocular hypotensive effects and side effects of two different topically applied prostaglandin (PG) esters were evaluated in a double masked study in 12 healthy males. Three doses of 15-propionat-PGF2 alpha-isopropylester (15-prop-PGF2 alpha-IE), two doses of PGF2 alpha-isopropylester (PGF2 alpha-IE), and placebo were compared. At equipotent doses 15-prop-PGF2 alpha-IE caused similar ocular side effects as PGF2 alpha-IE. It is concluded that both PGF2 alpha-IE and 15-prop-PGF2 alpha-IE reduce the IOP in normal eyes, but the use of a diester such as 15-prop-PGF2 alpha-IE does not provide a better separation between effect on IOP and side effects than PGF2 alpha-IE.

摘要

在一项针对12名健康男性的双盲研究中，评估了两种不同局部应用的前列腺素（PG）酯的降眼压作用和副作用。比较了15-丙酸-PGF2α-异丙酯（15-prop-PGF2α-IE）的三种剂量、PGF2α-异丙酯（PGF2α-IE）的两种剂量以及安慰剂。在等效剂量下，15-prop-PGF2α-IE引起的眼部副作用与PGF2α-IE相似。结论是，PGF2α-IE和15-prop-PGF2α-IE均可降低正常眼的眼压，但与PGF2α-IE相比，使用15-prop-PGF2α-IE这种二酯并不能在眼压作用和副作用之间实现更好的区分。