Shibata T, Kaneko N, Hara Y, Saito T, Sakaguchi H
Second Department of Pathology, Saitama Medical School, Japan.
Acta Pathol Jpn. 1990 Jun;40(6):448-57. doi: 10.1111/j.1440-1827.1990.tb01586.x.
A 41-year-old Japanese woman with lipoprotein glomerulopathy is reported. The patient presented with nephrotic syndrome, hyperlipoproteinemia and an increased level of plasma Apo E. The damaged glomeruli showed various degrees of capillary dilatation and accumulation of some material-often showing stratification, along with mesangial proliferation and mesangial interposition. The accumulated material was stained positive for beta-lipoprotein by the indirect immunoperoxidase technique. Capillary dilatation resulted from gradual accumulation of the lipoprotein as well as destruction of the mesangium, as if being torn off, due to increased intraluminal pressure. The patient's eldest sister also suffers from the same renal disease, suggesting a hereditary predisposition.
报告了一名患有脂蛋白肾小球病的41岁日本女性。该患者表现为肾病综合征、高脂蛋白血症和血浆载脂蛋白E水平升高。受损的肾小球显示出不同程度的毛细血管扩张以及一些物质的积聚——这些物质常呈分层状，同时伴有系膜增生和系膜插入。通过间接免疫过氧化物酶技术，积聚的物质对β-脂蛋白呈阳性染色。毛细血管扩张是由于脂蛋白的逐渐积聚以及系膜因管腔内压力升高而遭到破坏，就好像被撕开一样。患者的大姐也患有同样的肾脏疾病，提示存在遗传易感性。
