Fazekas T, Szekeres L
First Department of Medicine, Szent-Györgyi Albert University Medical School, Szeged, Hungary.
Acta Physiol Hung. 1990;75(3):229-36.
The mechanism of the proarrhythmic action of the Na+ and Ca++ channel blocking agent lidoflazine (Clinium) in animal experiments was analysed. Lidoflazine pretreatment was found to increase the electrically induced atrial fibrillatory threshold in the intact cat, but to decrease this parameter in the ventricular heart muscle. The changes induced by lidoflazine in the ventricular repolarization of the normoxic dog heart (T wave flattening, appearance of prominent U waves, T-U fusion, QT/QTU prolongation) are considered to be proarrhythmic ECG signs.
分析了钠通道和钙通道阻滞剂利多氟嗪（Clinium）在动物实验中的促心律失常作用机制。研究发现，利多氟嗪预处理可提高完整猫的电诱导心房颤动阈值，但会降低心室心肌的这一参数。利多氟嗪在常氧犬心脏心室复极化过程中引起的变化（T波平坦、出现明显U波、T-U融合、QT/QTU延长）被认为是促心律失常的心电图表现。
