Hanley S P, Hampton J R
Eur Heart J. 1983 Dec;4(12):889-93. doi: 10.1093/oxfordjournals.eurheartj.a061417.
Twenty-four patients received either propranolol, lidoflazine (Clinium), or propranolol/lidoflazine combinations in a study designed to evaluate the effect of these drugs in angina pectoris. Five patients developed ventricular tachycardia when receiving either lidoflazine or lidoflazine and propranolol in combination; one of these patients died. In addition, one patient died suddenly while being treated with propranolol alone. Lidoflazine therapy was associated with a significant prolongation of the QT interval of the electrocardiogram. Lidoflazine either alone or in combination with propranolol, appears to induce ventricular tachycardia.
在一项旨在评估这些药物对心绞痛疗效的研究中，24名患者接受了普萘洛尔、利多氟嗪（Clinium）或普萘洛尔/利多氟嗪联合用药。5名患者在接受利多氟嗪或利多氟嗪与普萘洛尔联合用药时出现室性心动过速；其中1名患者死亡。此外，1名患者在单独接受普萘洛尔治疗时突然死亡。利多氟嗪治疗与心电图QT间期显著延长有关。单独使用或与普萘洛尔联合使用时，利多氟嗪似乎都会诱发室性心动过速。
