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Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model.人脐血单个核细胞对匹罗卡品诱导癫痫模型的抗癫痫和神经保护作用。
Cytotechnology. 2014 Mar;66(2):193-9. doi: 10.1007/s10616-013-9557-3. Epub 2013 Aug 9.
2
Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting.慢性癫痫毛果芸香碱模型中癫痫发作的环路机制：细胞丢失和苔藓纤维发芽
Epilepsia. 1993 Nov-Dec;34(6):985-95. doi: 10.1111/j.1528-1157.1993.tb02123.x.
3
Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy.电击可延迟癫痫发作及随后的癫痫发生，但在锂-匹罗卡品癫痫模型中并不能预防神经元损伤。
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4
Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.在颞叶癫痫的锂-匹罗卡品模型中，vigabatrin可预防海马损伤，但不具有抗癫痫发生作用。
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Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.未成熟和成年大鼠锂-匹罗卡品癫痫模型慢性期神经元丢失与发作间期葡萄糖代谢之间的关系
Exp Neurol. 2001 Feb;167(2):227-41. doi: 10.1006/exnr.2000.7561.
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Prolonged low-dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium-pilocarpine model in the rat.在大鼠的锂-匹罗卡品模型中，长期低剂量咖啡因暴露可预防海马损伤，但不能预防癫痫的发生。
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Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.合理的多药治疗可有效终止锂-匹罗卡品大鼠癫痫持续状态：预防癫痫的机会窗口和生物标志物预测癫痫。
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Hippocampus. 2001;11(4):452-68. doi: 10.1002/hipo.1060.
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Xenograft of human umbilical mesenchymal stem cells from Wharton's jelly as a potential therapy for rat pilocarpine-induced epilepsy.人脐带华通氏胶间充质干细胞异种移植作为一种潜在疗法治疗匹罗卡品诱导的大鼠癫痫。
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Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy.实验性癫痫急性期骨髓细胞移植对癫痫发作的预防和海马功能重组的作用。
Seizure. 2010 Mar;19(2):84-92. doi: 10.1016/j.seizure.2009.12.003. Epub 2010 Jan 18.

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Cells. 2022 Dec 19;11(24):4129. doi: 10.3390/cells11244129.
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hUMSC vs. hUMSC-Exosome: Which One Is Better for Epilepsy?人脐带间充质干细胞与人脐带间充质干细胞外泌体：哪一种对癫痫更有效？
Pharmaceuticals (Basel). 2022 Oct 10;15(10):1247. doi: 10.3390/ph15101247.
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Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome.脐带来源的间充质干细胞对杜氏肌营养不良症诱导多能干细胞模型的改善作用。
Mol Neurobiol. 2022 Feb;59(2):748-761. doi: 10.1007/s12035-021-02633-1. Epub 2021 Nov 11.
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Is there a place for cellular therapy in depression?细胞疗法在抑郁症治疗中是否有一席之地？
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6
Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy.自体脂肪源性再生细胞鞘内输注治疗自身免疫性难治性癫痫：安全性和有效性评估
Stem Cells Int. 2020 Jan 3;2020:7104243. doi: 10.1155/2020/7104243. eCollection 2020.
7
Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies.细胞外囊泡作为结构性癫痫的诊断和治疗方法。
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Multiple Autologous Bone Marrow-Derived CD271 Mesenchymal Stem Cell Transplantation Overcomes Drug-Resistant Epilepsy in Children.多次同种异体骨髓源性 CD271 间充质干细胞移植克服儿童耐药性癫痫。
Stem Cells Transl Med. 2018 Jan;7(1):20-33. doi: 10.1002/sctm.17-0041. Epub 2017 Dec 10.
10
Contemplating stem cell therapy for epilepsy-induced neuropsychiatric symptoms.正在考虑采用干细胞疗法治疗癫痫诱发的神经精神症状。
Neuropsychiatr Dis Treat. 2017 Feb 23;13:585-596. doi: 10.2147/NDT.S114786. eCollection 2017.

本文引用的文献

1
Mesenchymal stem cells exert a remarkable regenerative effect requiring minimal CNS integration: commentary on: "Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function" by Voulgari-Kokota et al.间充质干细胞具有显著的再生效应，仅需最小程度的中枢神经系统整合：评论：“间充质干细胞通过抑制谷氨酸受体表达和功能来保护中枢神经系统神经元免受谷氨酸兴奋性毒性”，Voulgari-Kokota 等人。
Exp Neurol. 2013 Sep;247:292-5. doi: 10.1016/j.expneurol.2013.01.028. Epub 2013 Feb 4.
2
Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats.骨髓单核细胞移植可减少癫痫大鼠的发作频率，减轻神经元丢失，并调节促炎细胞因子的产生。
Neurobiol Dis. 2012 May;46(2):302-13. doi: 10.1016/j.nbd.2011.12.001. Epub 2011 Dec 11.
3
Brain inflammation as a biomarker in epilepsy.脑炎症作为癫痫的生物标志物。
Biomark Med. 2011 Oct;5(5):607-14. doi: 10.2217/bmm.11.61.
4
Epilepsy and brain inflammation.癫痫与脑炎症候群
Exp Neurol. 2013 Jun;244:11-21. doi: 10.1016/j.expneurol.2011.09.033. Epub 2011 Oct 1.
5
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.骨髓单核细胞可减少慢性癫痫大鼠的发作频率并改善认知结果。
Life Sci. 2011 Aug 15;89(7-8):229-34. doi: 10.1016/j.lfs.2011.06.006. Epub 2011 Jun 22.
6
Neuroprotection by human umbilical cord blood-derived progenitors in ischemic brain injuries.人脐带血来源的祖细胞对缺血性脑损伤的神经保护作用。
Arch Ital Biol. 2011 Jun;149(2):233-45. doi: 10.4449/aib.v149i2.1370.
7
Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus.在匹罗卡品诱导的癫痫持续状态后 4 周内，海马中 FGF-2 和 BDNF 的局部过表达可减少苔藓纤维的发芽和自发性癫痫发作。
Epilepsia. 2011 Mar;52(3):572-8. doi: 10.1111/j.1528-1167.2010.02930.x. Epub 2011 Jan 26.
8
Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research.脑损伤后癫痫发生的预防或修饰：实验方法和转化研究。
Pharmacol Rev. 2010 Dec;62(4):668-700. doi: 10.1124/pr.110.003046.
9
Estimation of nuclear population from microtome sections.从切片估计核数量。
Anat Rec. 1946 Feb;94:239-47. doi: 10.1002/ar.1090940210.
10
Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?神经生长因子是否适合作为预防癫痫发生的治疗靶点？
Epilepsia. 2010 Jul;51 Suppl 3:48-51. doi: 10.1111/j.1528-1167.2010.02609.x.

人脐血单个核细胞对匹罗卡品诱导癫痫模型的抗癫痫和神经保护作用。

Antiepileptic and neuroprotective effects of human umbilical cord blood mononuclear cells in a pilocarpine-induced epilepsy model.

机构信息

Centro de Biotecnologia e Terapia Celular, Hospital São Rafael, Av. S Rafael, Salvador, BA, 2152-41253-190, Brazil.

出版信息

Cytotechnology. 2014 Mar;66(2):193-9. doi: 10.1007/s10616-013-9557-3. Epub 2013 Aug 9.

DOI:10.1007/s10616-013-9557-3
PMID:23929461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3918271/
Abstract

Status epilepticus (SE) is a condition of persistent seizure that leads to brain damage and, frequently, to the establishment of chronic epilepsy. Cord blood is an important source of adult stem cells for the treatment of neurological disorders. The present study aimed to evaluate the effects of human umbilical cord blood mononuclear cells (HUCBC) transplanted into rats after induction of SE by the administration of lithium and pilocarpine chloride. Transplantation of HUCBC into epileptic rats protected against neuronal loss in the hippocampal subfields CA1, CA3 and in the hilus of the dentate gyrus, up to 300 days after SE induction. Moreover, transplanted rats had reduced frequency and duration of spontaneous recurrent seizures (SRS) 15, 120 and 300 days after the SE. Our study shows that HUCBC provide prominent antiepileptic and neuroprotective effects in the experimental model of epilepsy and reinforces that early interventions can protect the brain against the establishment of epilepsy.

摘要

癫痫持续状态（SE）是一种持续癫痫发作的状态，可导致脑损伤，并经常导致慢性癫痫的发生。脐血是治疗神经紊乱的成人干细胞的重要来源。本研究旨在评估在 SE 诱导后通过给予氯化锂和匹罗卡品，将人脐血单核细胞（HUCBC）移植到大鼠体内的效果。将 HUCBC 移植到癫痫大鼠体内，可以防止 SE 诱导后 300 天内海马 CA1、CA3 区和齿状回门区的神经元丢失。此外，移植后的大鼠在 SE 后 15、120 和 300 天，自发性反复发作性癫痫（SRS）的频率和持续时间降低。我们的研究表明，HUCBC 在癫痫实验模型中提供了显著的抗癫痫和神经保护作用，并且强化了早期干预可以保护大脑免受癫痫的发生。