Department of Chemistry, School of Science, MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an, 710049, P.R. China; Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.
Macromol Rapid Commun. 2013 Sep;34(18):1464-70. doi: 10.1002/marc.201300494. Epub 2013 Aug 9.
A dextran-based self-healing hydrogel is prepared by reversible Diels-Alder reaction under physiological conditions. Cytocompatible fulvene-modified dextran as main polymer chains and dichloromaleic-acid-modified poly(ethylene glycol) as cross-linkers are used. Both macro- and microscopic observation as well as the rheological recovery test confirm the self-healing property of the dextran-l-poly(ethylene glycol) hydrogels ("l" means "linked-by"). In addition, scanning electrochemical microscopy is used to qualitatively and quantitatively in situ track the self-healing process of the hydrogel for the first time. It is found that the longitudinal depth of scratch on hydrogel surface almost completely healed at 37 °C after 7 h. This work represents a facile approach for fabrication of polysaccharide self-healing hydrogel, which can be potentially used in several biomedical fields.
一种基于葡聚糖的自修复水凝胶是通过生理条件下的可逆 Diels-Alder 反应制备的。使用细胞相容性富烯修饰的葡聚糖作为主聚合物链和二氯马来酸修饰的聚（乙二醇）作为交联剂。宏观和微观观察以及流变恢复测试都证实了葡聚糖-l-聚（乙二醇）水凝胶的自修复性能（“l”表示“通过连接”）。此外，扫描电化学显微镜首次被用于定性和定量原位跟踪水凝胶的自修复过程。结果发现，水凝胶表面划痕的纵向深度在 37°C 下经过 7 小时几乎完全愈合。这项工作为多糖自修复水凝胶的制备提供了一种简便的方法，有望在几个生物医学领域得到应用。
