Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR22-CNRS, 23 rue du Loess, Boîte Postale 84047, 67034 Strasbourg Cedex 2, France.
Science. 2013 Aug 9;341(6146):1238149. doi: 10.1126/science.1238149.
Sequence-controlled polymers are macromolecules in which monomer units of different chemical nature are arranged in an ordered fashion. The most prominent examples are biological and have been studied and used primarily by molecular biologists and biochemists. However, recent progress in protein- and DNA-based nanotechnologies has shown the relevance of sequence-controlled polymers to nonbiological applications, including data storage, nanoelectronics, and catalysis. In addition, synthetic polymer chemistry has provided interesting routes for preparing nonnatural sequence-controlled polymers. Although these synthetic macromolecules do not yet compare in functional scope with their natural counterparts, they open up opportunities for controlling the structure, self-assembly, and macroscopic properties of polymer materials.
序列控制聚合物是其中单体单元具有不同化学性质的大分子，以有序的方式排列。最突出的例子是生物序列控制聚合物，主要由分子生物学家和生物化学家进行研究和使用。然而，最近在基于蛋白质和 DNA 的纳米技术方面的进展表明，序列控制聚合物与非生物应用有关，包括数据存储、纳米电子学和催化。此外，合成聚合物化学为制备非天然序列控制聚合物提供了有趣的途径。尽管这些合成大分子在功能范围上还不能与天然大分子相比，但它们为控制聚合物材料的结构、自组装和宏观性质提供了机会。
