Santhosh S B, Ambi Arun B, Hiremath R R, Mannur V S
Department of Bhaishajya Kalpana, KLE's Shri BMK Ayurveda Mahavidhyalaya, Shahapur, Belgaum, Karnataka, India.
Anc Sci Life. 2012 Jul;32(1):34-7. doi: 10.4103/0257-7941.113802.
Āmalaki (Embelica officinalis Gaertn.) is one of the most celebrated herbs in the Indian system of traditional medicine. It is one of the best Rasāyana-s (health promoting) drug. In Dugdhāmalakyādi yoga, Āmalaki (Embelica officinalis Gaertn.) powder is administered along with milk in case of svarabhaṅga (hoarseness of voice). Here an attempt is made to convert this formulation into chewable tablet without altering its property to improve its palatability, shelf life and fixation of proper therapeutic dose.
Chewable tablets were prepared by wet granulation method. Here, Āmalaki powder was prepared initially and it was mixed with additives and preservatives. Granules were prepared from this mixture by adding binding agent, finally compressed in to tablets.
The physico-chemical analysis of Āmalaki standard are: Foreign Matter-Nil, Acid insoluble Ash-0.51%w/w, Water soluble Ash-2.01% w/w, Alcoholic Extractives-44.48%, Aqueous Extractives 67.52%, pH-3.1, Moisture content-8.19%. Quality control test for chewable tablet was carried out and found satisfactory with general characteristics of tablet viz. hardness 1.8, disintegration time 15-20 min, friability 0.5%, weight variation +/- 3%. The TLC of Āmalaki powder showed 3 spots with Rf value 0.14, 0.4, and 0.73 and the chewable tablets showed 2 spots with Rf value 0.31 and 0.89 under 254 nm. The adaptation of modern techniques or methods to convert the Ayurvedic formulations without altering its therapeutic property is necessary to made them suitable for the present trends of newer drug delivery dosage forms.
余甘子（Phyllanthus emblica Linn.）是印度传统医学体系中最著名的草药之一。它是最佳的rasāyana-s（促进健康）药物之一。在Dugdhāmalakyādi瑜伽中，对于声嘶（声音嘶哑），余甘子（Phyllanthus emblica Linn.）粉末与牛奶一起服用。在此，尝试将该制剂转化为咀嚼片，同时不改变其性质，以提高其适口性、保质期并固定合适的治疗剂量。
采用湿法制粒法制备咀嚼片。在此，首先制备余甘子粉末，并将其与添加剂和防腐剂混合。通过加入粘合剂由该混合物制备颗粒，最后压制成片。
余甘子标准品的理化分析结果为：杂质-无，酸不溶性灰分-0.51%w/w，水溶性灰分-2.01%w/w，醇溶性浸出物-44.48%，水溶性浸出物67.52%，pH-3.1，水分含量-8.19%。对咀嚼片进行了质量控制测试，发现其片剂的一般特性令人满意，即硬度1.8，崩解时间15 - 20分钟，脆碎度0.5%，重量差异+/- 3%。余甘子粉末的薄层色谱在254nm下显示3个斑点，比移值分别为0.14、0.4和0.73，咀嚼片显示2个斑点，比移值分别为0.31和0.89。在不改变其治疗特性的情况下，采用现代技术或方法来转化阿育吠陀制剂，使其适合新型药物递送剂型的当前趋势是必要的。
