博内鸡骨常山茎皮粉末片的制剂与评价
Formulation and Evaluation of Alstonia boonei Stem Bark Powder Tablets.
作者信息
Chime Salome A, Ugwuoke E C, Onyishi I V, Brown S A, Onunkwo G C
机构信息
Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410 001, Nigeria.
出版信息
Indian J Pharm Sci. 2013 Mar;75(2):226-30.
The aim of this work was to formulate Alstonia boonei dried stem bark powder into tablets by wet granulation method using acacia, gelatine and sodium carboxymethyl cellulose as binders at concentrations of 1, 2, 4 and 8% w/w. The phytochemistry of the stem bark of Alstonia boonei was evaluated. The micromeritic properties of the granules prepared were studied. The tablets were evaluated using the necessary official and unofficial tests. The results of the phytochemical analysis showed that alkaloids, tannins, steroids, saponins, glycosides, flavonoids and terpenoids were present while anthroquinones and acidcompounds were absent. Micromeritic studies showed that Alstonia boonei granules had good flowability. The formulated tablets complied with British Pharmacopoeial specification for weight uniformity, hardness (≥5 kgf) and tablet friability (<1%). For disintegration test, tablets formulated with gelatine and acacia at concentrations of 1, 2 and 4% w/w complied with Pharmacopoeial specification. However, tablets formulated with SCMC (1-8% w/w) and 8% w/w of acacia and gelatine failed the disintegration tests (Disintegration time more than 15 min).
本研究的目的是采用湿法制粒工艺，以阿拉伯胶、明胶和羧甲基纤维素钠为粘合剂，浓度分别为1%、2%、4%和8%（w/w），将布氏鸡骨常山干燥茎皮粉末制成片剂。对布氏鸡骨常山茎皮进行了植物化学分析。研究了所制备颗粒的粉体学性质。采用必要的官方和非官方试验对片剂进行评价。植物化学分析结果表明，存在生物碱、单宁、甾体、皂苷、糖苷、黄酮类化合物和萜类化合物，而不存在蒽醌和酸性化合物。粉体学研究表明，布氏鸡骨常山颗粒具有良好的流动性。所制备的片剂符合英国药典关于重量均匀度、硬度（≥5 kgf）和片剂脆碎度（<1%）的规定。在崩解试验中，以1%、2%和4%（w/w）的明胶和阿拉伯胶制备的片剂符合药典规定。然而，以SCMC（1 - 8% w/w）以及8%（w/w）的阿拉伯胶和明胶制备的片剂崩解试验不合格（崩解时间超过15分钟）。
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