Mazess R B, Barden H S, Ohlrich E S
Department of Medical Physics and the Eating Disorders Clinic, University of Wisconsin, Madison.
Am J Clin Nutr. 1990 Sep;52(3):438-41. doi: 10.1093/ajcn/52.3.438.
Eleven female patients (aged 18-46 y) with anorexia nervosa were measured by use of dual-photon absorptiometry for 1) bone mineral content (BMC, in g) and bone mineral density (BMD, in g/cm2) of the total skeleton and its regions, 2) BMD of the lumbar spine and the proximal femur, and 3) total body soft-tissue composition. The patients weighed 44.4 kg, approximately 15 kg less than normal peers (n = 22). The fat mass (3.35 kg) and content of soft tissue (7.8%) were four and three times lower (p less than 0.001) respectively, than those in normal women (15.1 kg and 26%, respectively). The total skeleton mineral (1921 g) was approximately 25% less than that of young normal women. The BMC as a fraction of the lean tissue mass was approximately 4.9% in the patients and 5.9% in normal women. Total body and femoral BMD averaged only 10% and 13% lower than those of normal women, respectively; however, spinal BMD was particularly reduced (approximately 25%, p less than 0.001).
对11名神经性厌食症女性患者（年龄18 - 46岁）采用双能X线吸收法进行测量，以测定：1）全身及其各部位的骨矿物质含量（BMC，单位：g）和骨矿物质密度（BMD，单位：g/cm²）；2）腰椎和股骨近端的BMD；3）全身软组织成分。这些患者体重为44.4 kg，比正常同龄人（n = 22）轻约15 kg。脂肪量（3.35 kg）和软组织含量（7.8%）分别比正常女性（分别为15.1 kg和26%）低四倍和三倍（p < 0.001）。全身骨骼矿物质（1921 g）比年轻正常女性少约25%。患者的BMC占瘦体重的比例约为4.9%，正常女性为5.9%。全身和股骨的BMD分别仅比正常女性低10%和13%；然而，脊柱BMD明显降低（约25%，p < 0.001）。
