Parsons B N, Crayford G, Humphrey T J, Wigley P
a Zoonotic Infection of Pigs and Poultry Group, Institute of Infection & Global Health , University of Liverpool , Leahurst Campus, Wirral , UK.
Avian Pathol. 2013;42(5):443-6. doi: 10.1080/03079457.2013.822469. Epub 2013 Aug 9.
Antimicrobial-resistant Salmonella enterica poses a particular risk to public health, and in particular isolates belonging to clonal lineages such as Salmonella Typhimurium DT104 cause epidemics across species including poultry. In recent years, antimicrobial-resistant S. Typhimurium DT193 and specifically the monophasic S. Typhimurium-like variants of this phage type, serotypes 4,12:i:- and 4,5,12:i:-, have become an increasing risk to public health in Europe and the USA and now account for nearly one-half of human S. Typhimurium infections in the UK. Unlike S. Typhimurium that possesses two forms of flagella which can vary between phase 1 and phase 2 during infection, monophasic variants possess only phase 1 flagella. These monophasic antimicrobial-resistant variants have become a major problem in pig production but human cases have also been associated with poultry consumption and have been found in UK flocks through surveillance schemes since 2010. In this study we determined the ability of antimicrobial-resistant DT193 serotype 4,12:i:- and 4,5,12:i:- isolates from pigs to infect chickens. All isolates were found to colonize the caeca and liver. All but one isolate of serotype 4,5,12:i:- also infected the spleen. Levels of infection and pathology were comparable with those found with the virulent S. Typhimurium isolate 4/74. These findings indicate that both S. Typhimurium DT193 and monophasic variants of this phage type usually associated with pigs are capable of colonizing the chicken. This shows that both S. Typhimurium DT193 and monophasic variants represent a significant and potential emerging threat to poultry production from "spill-over" of these isolates from the pig industry or other sources.
耐抗菌药物的肠炎沙门氏菌对公众健康构成了特殊风险，尤其是属于克隆谱系的菌株，如鼠伤寒沙门氏菌DT104会在包括家禽在内的多个物种中引发疫情。近年来，耐抗菌药物的鼠伤寒沙门氏菌DT193，特别是该噬菌体类型的单相鼠伤寒沙门氏菌样变体，血清型4,12:i:-和4,5,12:i:-，对欧洲和美国的公众健康构成了越来越大的风险，目前在英国占人类鼠伤寒沙门氏菌感染病例的近一半。与具有两种鞭毛形式且在感染过程中可在第1相和第2相之间变化的鼠伤寒沙门氏菌不同，单相变体仅具有第1相鞭毛。这些单相耐抗菌药物变体已成为生猪生产中的一个主要问题，但人类病例也与食用家禽有关，并且自2010年以来通过监测计划在英国鸡群中被发现。在本研究中，我们测定了来自猪的耐抗菌药物DT193血清型4,12:i:-和4,5,12:i:-分离株感染鸡的能力。所有分离株均被发现可在盲肠和肝脏中定植。除一株血清型4,5,12:i:-分离株外，所有分离株还感染了脾脏。感染水平和病理情况与强毒株鼠伤寒沙门氏菌分离株4/74相当。这些发现表明，鼠伤寒沙门氏菌DT193及其通常与猪相关的该噬菌体类型的单相变体都能够在鸡体内定植。这表明鼠伤寒沙门氏菌DT193和单相变体都代表了这些分离株从养猪业或其他来源“溢出”对家禽生产构成的重大且潜在的新威胁。
