Faculty of Health Sciences, Fernando Pessoa University (FCS-UFP) , Porto , Portugal .
Pharm Dev Technol. 2014 Sep;19(6):677-80. doi: 10.3109/10837450.2013.823989. Epub 2013 Aug 12.
The aim of the present study is to design and characterize a rutin-loaded nanoemulsion (RT-NE) and determine the release profile of the drug in vitro. RT-NE was prepared by a high pressure homogenization technique. The obtained droplets were analyzed by optical microscopy and were shown to be of spherical shape. By dynamic light scattering, characterization of RT-NE showed an average diameter of 127 nm, polydispersity index of 0.168 and zeta potential values near neutrality (-3.49 mV). Encapsulation efficiency was of ∼82% (82.3 ± 1.62%). Drug release was characterized by an initial burst which decreased over the time, showing a sustained release profile. After 24 h, rutin released from NE reached nearly 65%. The developed system proved to be stable and suitable to encapsulating poorly water-soluble drugs.
本研究旨在设计和表征槲皮素负载纳米乳（RT-NE），并确定药物的体外释放特征。RT-NE 是通过高压均质技术制备的。通过光学显微镜分析得到的液滴呈球形。通过动态光散射，对 RT-NE 的表征显示平均直径为 127nm，多分散指数为 0.168，zeta 电位值接近中性（-3.49mV）。包封效率约为 82%（82.3±1.62%）。药物释放特征表现为初始突释，随后逐渐减少，呈现出持续释放的特征。24 小时后，从 NE 中释放的槲皮素接近 65%。该系统稳定且适用于包封疏水性差的药物。
