Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Cell Biology, Yale University, New Haven, CT, United States.
Curr Opin Neurobiol. 2013 Dec;23(6):1018-26. doi: 10.1016/j.conb.2013.07.004. Epub 2013 Aug 6.
Proper circuit connectivity is critical for nervous system function. Connectivity derives from the interaction of two interdependent modules: synaptic specificity and synaptic assembly. Specificity involves both targeting of neurons to specific laminar regions and the formation of synapses onto defined subcellular areas. In this review, we focus discussion on recently elucidated molecular mechanisms that control synaptic specificity and link them to synapse assembly. We use these molecular pathways to underscore fundamental cell biological concepts that underpin, and help explain, the rules governing synaptic specificity.
适当的电路连接对于神经系统功能至关重要。连接源自两个相互依存的模块的相互作用:突触特异性和突触组装。特异性既涉及神经元靶向特定层区域,又涉及形成突触到定义的亚细胞区域。在这篇综述中,我们重点讨论了最近阐明的控制突触特异性并将其与突触组装联系起来的分子机制。我们使用这些分子途径强调了基础细胞生物学概念,这些概念为突触特异性的规则提供了基础,并有助于解释这些规则。