Mol Cell. 2013 Aug 8;51(3):275-6. doi: 10.1016/j.molcel.2013.07.020.
B cell lymphomas are characterized by recurrent chromosomal translocations. Why these events are so prevalent is an area of active investigation. Several ideas have been put forward to try to explain this phenomenon, including: nuclear proximity between translocating genes; repeated DNA damage by enzymes that mediate gene recombination (AID and RAGs); and selection for deregulated oncogenes.
B 细胞淋巴瘤的特征是反复出现染色体易位。这些事件如此普遍的原因是一个活跃的研究领域。已经提出了几种想法来试图解释这种现象,包括:易位基因之间的核接近;介导基因重组的酶(AID 和 RAGs)引起的重复 DNA 损伤;以及选择失调控的癌基因。