Otto G, Fox J G, Wu P Y, Taylor N S
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
Antimicrob Agents Chemother. 1990 Jun;34(6):1232-6. doi: 10.1128/AAC.34.6.1232.
Colonization of the ferret stomach by Helicobacter mustelae has been suggested as a possible animal model for Helicobacter pylori-associated gastroduodenal disease of humans. Our study was designed to determine whether antimicrobial chemotherapy could eradicate H. mustelae from ferrets. Triple antimicrobial therapy combining amoxicillin, metronidazole, and bismuth subsalicylate was successful in eradicating the organism from 5 of 7 (71%) adult ferrets. Despite apparent in vitro susceptibility, neither chloramphenicol monotherapy nor a polytherapeutic regimen combining tetracycline, metronidazole, and bismuth subsalicylate proved effective in the eradication of H. mustelae. Several strains isolated after unsuccessful polytherapy showed markedly increased resistance to metronidazole. These preliminary findings are similar to results of H. pylori treatment trials with humans and suggest that the ferret may be a useful model for evaluating and comparing potential antimicrobial modalities for the eradication of H. pylori.
雪貂胃部被幽门螺杆菌定植被认为可能是人类幽门螺杆菌相关胃十二指肠疾病的一种动物模型。我们的研究旨在确定抗菌化疗能否从雪貂体内根除幽门螺杆菌。阿莫西林、甲硝唑和次水杨酸铋联合的三联抗菌疗法成功地从7只成年雪貂中的5只（71%）根除了该菌。尽管在体外药敏试验中显示有敏感性，但氯霉素单药治疗以及四环素、甲硝唑和次水杨酸铋联合的多药治疗方案均未有效根除幽门螺杆菌。多药治疗失败后分离出的几株菌株对甲硝唑的耐药性显著增加。这些初步发现与人类幽门螺杆菌治疗试验的结果相似，表明雪貂可能是评估和比较根除幽门螺杆菌潜在抗菌方法的有用模型。
