Wuxi Mental Health Center, Wuxi 214151, Jiangsu Province, China.
Neurosci Lett. 2013 Sep 27;552:120-3. doi: 10.1016/j.neulet.2013.07.051. Epub 2013 Aug 8.
Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified a single-nucleotide polymorphism (SNP, rs10489202) in the mitochondrial pyruvate carrier 2 gene (MPC2, also known as BRP44) as a possible susceptibility locus for schizophrenia. Hoping to validate this finding, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls, using the LDR-PCR method to genotype polymorphisms (rs10489202 and a TagSNP rs203861) in the MPC2 gene. However, we found no significant difference (P>0.05) in either allele or genotype frequency in the SNPs between patients and controls. These results did not support the previous finding suggesting the further study by using a large-scale association analysis in the future should be warranted in Han Chinese populations.
精神分裂症（SCZ）是一种常见的、复杂的和严重的精神疾病，与许多不同的遗传和环境风险因素有关。最近一项针对汉族人的全基因组关联研究（GWAS）发现，线粒体丙酮酸载体 2 基因（MPC2，也称为 BRP44）中的单核苷酸多态性（SNP，rs10489202）可能是精神分裂症的易感基因座。为了验证这一发现，我们对 1093 例精神分裂症患者和 1022 例健康对照进行了一项汉族人的病例对照研究，采用 LDR-PCR 方法对 MPC2 基因中的多态性（rs10489202 和 TagSNP rs203861）进行基因分型。然而，我们在患者和对照组之间的 SNPs 中未发现等位基因或基因型频率有显著差异（P＞0.05）。这些结果不支持先前的发现，提示未来在汉族人群中应进行大规模关联分析以进一步研究。
