Liu Yansong, Cheng Zaohuo, Wang Jun, Jin Chunhui, Yuan Jianmin, Wang Guoqiang, Zhang Fuquan, Zhao Xudong
Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China.
Wuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
BMC Psychiatry. 2016 Jul 4;16:206. doi: 10.1186/s12888-016-0923-5.
Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI multiple domains 1 (CSMD1) gene as a risk factor for SCZ. In this study, we investigated whether the rs10503253 in CSMD1 contributes to the risk of SCZ in a Han Chinese population.
We conducted a case-control study in a population from eastern China, involving 1378 SCZ patients and 1091 unrelated healthy controls, using the ligase detection reaction-polymerase chain reaction method to genotype the rs10503253 polymorphism in the CSMD1 gene.
No significant association was found between the SCZ patients and controls for any allele or genotype frequency of the SNP rs10503253 (all P > 0.05).
Our findings do not support an association between CSMD1 rs10503253 and SCZ in a Han Chinese population.
精神分裂症（SCZ）是一种复杂、具有遗传性且具有破坏性的精神障碍。近期全基因组关联研究已确定CUB和SUSHI多结构域1（CSMD1）基因中的单核苷酸多态性（SNP；rs10503253）是SCZ的一个风险因素。在本研究中，我们调查了CSMD1基因中的rs10503253是否会增加中国汉族人群患SCZ的风险。
我们在中国东部人群中开展了一项病例对照研究，纳入1378例SCZ患者和1091名无亲缘关系的健康对照，采用连接酶检测反应-聚合酶链反应方法对CSMD1基因中的rs10503253多态性进行基因分型。
对于SNP rs10503253的任何等位基因或基因型频率，在SCZ患者与对照之间均未发现显著关联（所有P>0.05）。
我们的研究结果不支持CSMD1 rs10503253与中国汉族人群SCZ之间存在关联。
