1-乙基-3-碳酰肼和 3-[1-氧代-2-肼基-3-（对甲苯磺酰基）喹啉]衍生物的合成与研究及其对抗细菌感染的作用。
Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections.
机构信息
Department of Applied Chemistry, Faculty of Engineering and Technology, M.J.P. Rohilkhand University, Bareilly 243006, U.P., India.
出版信息
Eur J Med Chem. 2013 Sep;67:464-8. doi: 10.1016/j.ejmech.2013.06.056. Epub 2013 Jul 9.
We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a-e) and sulfonamide group (7a-e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro.
我们合成了一系列含有肼基（6a-e）和磺酰胺基（7a-e）取代基的新型喹诺酮衍生物。这些化合物被筛选出具有抗菌活性。所有这些化合物都通过光谱手段和元素分析进行了充分的表征。从最低抑菌浓度（MIC）数据可以看出，所有合成的化合物在体外均表现出良好的抗菌活性。
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