Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran.
Mol Divers. 2019 Aug;23(3):593-601. doi: 10.1007/s11030-018-9892-6. Epub 2018 Nov 23.
A one-pot, multi-component protocol for the synthesis of a new class of functionalized quinoline carbohydrazide derivatives via reaction of various anilines, dimedone, aromatic aldehydes, and cyanoacetohydrazide is described. The reactions are completed in the presence of catalytic amount of piperidine, respectively, in melt conditions and then in ethanol/water (1:1) as green solvent at 80 °C. Mild conditions, green medium, short reaction times, simple workup and purification process with no chromatographic technique, and good yields are the main advantages of this method.
本文描述了一种通过各种苯胺、二甲基酮、芳香醛和氰基乙酰胺反应一锅多组分合成新型功能化喹啉甲酰肼衍生物的方法。在熔融条件下，分别在催化量的哌啶存在下，然后在 80°C 的乙醇/水（1:1）绿色溶剂中完成反应。该方法具有温和的条件、绿色的介质、较短的反应时间、简单的后处理和纯化过程，无需使用色谱技术，并且产率较高，是该方法的主要优点。
