Department of Psychology and Neurology, University of Cincinnati, Cincinnati, OH 45221, USA.
J Parkinsons Dis. 2011;1(4):321-7. doi: 10.3233/JPD-2011-11042.
Cardiovascular autonomic dysfunction is a common non-motor symptom associated with synucleinopathies such as Parkinson's disease (PD). Several recent clinical studies indicate that cardiovascular autonomic impairments including orthostatic hypotension and sympathetic denervation may precede the development of the cardinal motor symptoms in PD, making cardiovascular dysfunction an attractive target for the development of biomarkers for early detection and potential neuroprotective strategies for PD. However, the pathologic mechanisms underlying cardiovascular dysfunction as well as many of the non-motor symptoms in PD remain unknown. This is likely due, in part, to an initial under-appreciation of PD as a systemic disorder as well as limited research in cardiovascular dysfunction in animal models of PD. Here, we highlight studies that have investigated cardiovascular dysfunction in rodent models of PD and the potential usefulness of genetic mouse models of PD for this endeavor.
心血管自主神经功能障碍是一种常见的非运动症状，与帕金森病（PD）等突触核蛋白病有关。最近的几项临床研究表明，心血管自主神经损伤，包括直立性低血压和交感神经去神经支配，可能先于 PD 主要运动症状的发展，使心血管功能障碍成为开发早期检测生物标志物和潜在 PD 神经保护策略的有吸引力的靶点。然而，PD 心血管功能障碍以及许多非运动症状的病理机制仍然未知。这可能部分归因于最初对 PD 作为一种系统性疾病的低估，以及 PD 动物模型中对心血管功能障碍的研究有限。在这里，我们重点介绍了研究 PD 啮齿动物模型中心血管功能障碍的研究，以及 PD 遗传小鼠模型在这方面的潜在用途。
