Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Second University of Naples, Via Costantinopoli, 16, 80100, Napoli, Italy.
Inflammation. 2013 Dec;36(6):1316-26. doi: 10.1007/s10753-013-9670-7.
Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120-coating protein, appears to be beneficial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-γ and TNF-α-NHEK activated cells. Moreover, we analysed the interference of PT and its analogues through STAT-3 activation. Our results show that the analogues tested exhibit the beneficial biological effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptidomimetics act directly, by reducing proinflammatory responses. Its reduction appears to be important for therapeutic approach in psoriasis pathogenesis.
肽 T（PT），一种位于 HIV-1 gp120 外壳蛋白 V2 区的八肽片段，似乎对治疗银屑病有益。我们之前的研究表明，角质形成细胞在调节 PT 在银屑病中的治疗效果方面起着关键作用。本研究旨在探讨 PT 及其肽模拟天然产物 Dhurrin 和 Prunasin 对 IFN-γ 和 TNF-α-NHEK 激活细胞中 IL-6、IL-8、IL-23、HSP70 和 ICAM-1 表达的影响。此外，我们分析了 PT 及其类似物通过 STAT-3 激活的干扰。我们的结果表明，所测试的类似物表现出 PT 的有益的生物学效应，表明角质形成细胞在 PT 和肽模拟物直接作用下发挥主要作用，通过减少炎症反应。其减少似乎对银屑病发病机制的治疗方法很重要。
