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[类风湿性关节炎患者的泌尿系统合并症:文献综述]

[Urological comorbidities in patients with rheumatoid arthritis : literature review].

作者信息

Friedl A, Mustak M, Höltl W, Erlacher L

机构信息

2. Med. Abteilung, Abteilung für Rheumatologie, Kaiser Franz-Josef-Spital, Sozialmedizinisches Zentrum Süd, Kundratstr., 1100, Wien, Österreich,

出版信息

Z Rheumatol. 2013 Nov;72(9):910-5. doi: 10.1007/s00393-013-1231-9.

Abstract

Patients with rheumatoid arthritis (RA) have an increased risk of urolithiasis which is further negatively impacted by a reduced bone density. Interstitial cystitis also tends to occur more often in patients with rheumatic diseases. The high incidence of bacterial urogenital infections is influenced by the use of immunomodulating drugs. Many RA patients have to undergo numerous tests until a diagnosis is reached and are then treated as outpatients on a tightly controlled schedule. Despite a closely controlled rheumatological follow-up, urological screening and determination of a baseline prostate-specific antigen (PSA) value (in men over 45 years old) should not be neglected. In patients with an increased risk of renal and bladder neoplasms or when such a diagnosis is known, the benefit of long-term use of high doses of non-steroidal anti-inflammatory drugs (NSAID, aspirin type) should be carefully weighed up with a risk profile and after specialist urological assessment. Patients who suffer from sexual dysfunction due to physical limitations and prolonged medical therapy should undergo urological and gynecological assessment to exclude contributing causes. The use of aphrodisiacs and erection-enhancing drugs (e.g. PDE5 inhibitors, local injection with prostaglandins and vacuum therapy) require prior approval by a medical specialist and also cardiovascular stability. Acute urinary retention is more common in chronic inflammatory musculoskeletal diseases.

摘要

类风湿性关节炎(RA)患者患尿石症的风险增加,而骨密度降低会进一步对其产生负面影响。间质性膀胱炎在风湿性疾病患者中也往往更常发生。免疫调节药物的使用会影响细菌性泌尿生殖系统感染的高发病率。许多RA患者在确诊前必须接受大量检查,然后作为门诊患者按照严格控制的时间表进行治疗。尽管进行了密切的风湿病随访,但泌尿系统筛查和测定基线前列腺特异性抗原(PSA)值(45岁以上男性)不应被忽视。对于肾和膀胱肿瘤风险增加的患者或已知患有此类疾病的患者,长期使用高剂量非甾体抗炎药(NSAID,阿司匹林类型)的益处应在进行风险评估并经泌尿外科专家评估后仔细权衡。因身体限制和长期药物治疗而患有性功能障碍的患者应接受泌尿外科和妇科评估,以排除促成因素。使用壮阳药和增强勃起的药物(如PDE5抑制剂、局部注射前列腺素和真空疗法)需要事先获得医学专家的批准,并且还需要心血管稳定。急性尿潴留在慢性炎症性肌肉骨骼疾病中更为常见。

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