将 MLL 与肝癌中的 HGF-MET 信号通路相联系。
Linking MLL and the HGF-MET signaling pathway in liver cancer.
机构信息
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
出版信息
J Clin Invest. 2013 Jul;123(7):2780-3. doi: 10.1172/JCI70235. Epub 2013 Jun 24.
Abstract
Mixed-lineage leukemia (MLL; also known as myeloid/lymphoid), the human homolog of trithorax in Drosophila, is a transcriptional coactivator that plays an essential role during early development and hematopoiesis. Furthermore, MLL is critically involved in the epigenetic regulation of cell cycle, senescence, DNA damage, and stem cell self-renewal. Chromosomal aberrations of MLL in acute leukemias are well documented, but the role of this gene in solid malignancies remains unclear. In this issue of the JCI, Takeda et al. describe a novel epigenetic link between MLL and the HGF-MET signaling pathway conferring invasive and metastatic properties to hepatocellular carcinoma cells.
摘要
混合谱系白血病（MLL；也称为髓系/淋巴系）是果蝇 trithorax 的人类同源物，是一种转录共激活因子，在早期发育和造血过程中发挥着重要作用。此外，MLL 还在细胞周期、衰老、DNA 损伤和干细胞自我更新的表观遗传调控中发挥关键作用。急性白血病中 MLL 的染色体异常已有充分记录，但该基因在实体恶性肿瘤中的作用尚不清楚。在本期 JCI 中，Takeda 等人描述了 MLL 与 HGF-MET 信号通路之间的新的表观遗传联系，该联系赋予肝癌细胞侵袭和转移特性。
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