• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis and biological evaluation of 1,2,4-triazole and 1,3,4-thiadiazole derivatives as potential cytotoxic agents.

作者信息

Shi Yao-Jie, Song Xue-Jiao, Li Xiao, Ye Ting-Hong, Xiong Ying, Yu Luo-Ting

机构信息

State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University.

出版信息

Chem Pharm Bull (Tokyo). 2013;61(11):1099-104. doi: 10.1248/cpb.c13-00242. Epub 2013 Aug 10.

DOI:10.1248/cpb.c13-00242
PMID:23934258
Abstract

A series of new 3-amino-5-sulfanyl-1,2,4-triazole and 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives have been synthesized and their cytotoxicities were evaluated on a panel of human cancer cell lines (BxPC-3, H1975, SKOV-3, A875, HCT116, etc.). The best one (compound 5m) exhibited activities with IC50 values ranging from 0.04 to 23.6 µM against nine human cancer cell lines. Further biological evaluation indicated that DNA replication was blocked by treatment with compound 5m in HCT116 cells.

摘要

相似文献

1
Synthesis and biological evaluation of 1,2,4-triazole and 1,3,4-thiadiazole derivatives as potential cytotoxic agents.
Chem Pharm Bull (Tokyo). 2013;61(11):1099-104. doi: 10.1248/cpb.c13-00242. Epub 2013 Aug 10.
2
Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety.3,4-二取代-5-(3,4,5-三甲氧基苯基)-4H-1,2,4-三唑和新型含 3,4,5-三甲氧基苯基部分的 5,6-二氢-[1,2,4]三唑并[3,4-b][1,3,4]噻二唑衍生物的合成及细胞毒性。
Bioorg Med Chem Lett. 2012 Jul 1;22(13):4471-4. doi: 10.1016/j.bmcl.2012.03.023. Epub 2012 Mar 11.
3
Synthesis and antiproliferative activity of some new thieno[2,3-d]pyrimidin-4(3H)-ones containing 1,2,4-triazole and 1,3,4-thiadiazole moiety.一些含有1,2,4-三唑和1,3,4-噻二唑部分的新型噻吩并[2,3-d]嘧啶-4(3H)-酮的合成及抗增殖活性
Eur J Med Chem. 2014 Oct 30;86:676-83. doi: 10.1016/j.ejmech.2014.09.032. Epub 2014 Sep 10.
4
Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole -glycosides.新型 1,3,4-噻二唑硫苷和 1,2,3-三唑基-1,3,4-噻二唑苷的合成及细胞毒性活性。
Molecules. 2019 Oct 16;24(20):3738. doi: 10.3390/molecules24203738.
5
Novel 1,2,4-triazole derivatives as antitumor agents against hepatocellular carcinoma.新型1,2,4-三唑衍生物作为抗肝细胞癌的抗肿瘤药物。
Chem Biol Interact. 2017 Aug 25;274:68-79. doi: 10.1016/j.cbi.2017.07.008. Epub 2017 Jul 8.
6
Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents.新型异恶唑和三唑连接的6-羟基香豆素作为强效细胞毒剂的合成及生物学评价
Bioorg Med Chem Lett. 2014 Sep 1;24(17):4243-6. doi: 10.1016/j.bmcl.2014.07.031. Epub 2014 Jul 17.
7
Synthesis and Biological Evaluation of Novel 1,3,4-thiadiazole Derivatives Incorporating Benzisoselenazolone Scaffold as Potential Antitumor Agents.新型含苯并异硒唑酮骨架的1,3,4-噻二唑衍生物作为潜在抗肿瘤药物的合成及生物学评价
Med Chem. 2016;12(7):631-639. doi: 10.2174/1573406412666160201120806.
8
Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents.新型2,5-二取代-1,3,4-噻二唑与1,2,4-三唑、1,3,4-噻二唑、1,3,4-恶二唑和/或席夫碱的合成作为潜在的抗菌和抗增殖剂
Molecules. 2015 Sep 2;20(9):16048-67. doi: 10.3390/molecules200916048.
9
Synthesis and biological evaluation of 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as a novel class of potential anti-tumor agents.新型潜在抗肿瘤药物3,6-二取代[1,2,4]三唑并[3,4-b][1,3,4]噻二唑衍生物的合成与生物学评价
Eur J Med Chem. 2009 Jul;44(7):2776-81. doi: 10.1016/j.ejmech.2009.01.003. Epub 2009 Jan 19.
10
Cytotoxicity of new 5-phenyl-4,5-dihydro-1,3,4-thiadiazole analogues.新型5-苯基-4,5-二氢-1,3,4-噻二唑类似物的细胞毒性
Chem Pharm Bull (Tokyo). 2011;59(11):1413-6. doi: 10.1248/cpb.59.1413.

引用本文的文献

1
Synthesis and Biological Evaluation of -Phenylalanine Derivatives Containing Sulphonamide and Azole Moieties as Antiproliferative Candidates in Lung Cancer Models.含磺酰胺和唑基部分的苯丙氨酸衍生物作为肺癌模型中抗增殖候选物的合成与生物学评价
Molecules. 2025 Aug 7;30(15):3303. doi: 10.3390/molecules30153303.
2
Synthesis and cytotoxic activity evaluation of some new 1, 3, 4-oxadiazole, 1, 3, 4-thiadiazole and 1, 2, 4- triazole derivatives attached to phthalimide.一些连接邻苯二甲酰亚胺的新型1,3,4-恶二唑、1,3,4-噻二唑和1,2,4-三唑衍生物的合成及细胞毒性活性评价
Res Pharm Sci. 2021 Oct 15;16(6):634-642. doi: 10.4103/1735-5362.327509. eCollection 2021 Dec.
3
Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development.
三唑修饰的拟肽：药物发现与开发的契机。
Front Chem. 2021 May 20;9:674705. doi: 10.3389/fchem.2021.674705. eCollection 2021.
4
Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives-A Review.1,3,4-噻二唑衍生物的细胞毒性性质综述。
Molecules. 2020 Sep 20;25(18):4309. doi: 10.3390/molecules25184309.
5
Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.1-(3',4',5'-三甲氧基苯甲酰基)-3-芳基氨基-5-氨基-1,2,4-三唑的合成、抗有丝分裂和抗血管活性
J Med Chem. 2014 Aug 14;57(15):6795-808. doi: 10.1021/jm5008193. Epub 2014 Jul 28.