Wegman-Ostrosky Talia, Soto-Reyes Ernesto, Vidal-Millán Silvia, Sánchez-Corona José
Instituto Nacional de Cancerología, División de Investigación, México Universidad de Guadalajara, Instituto de Génetica Humana, México.
Instituto Nacional de Cancerología, División de Investigación, México.
J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):227-33. doi: 10.1177/1470320313496858. Epub 2013 Aug 9.
The hallmarks of cancer are described as the distinctive and complementary capacities that cells must acquire during the multistep development of becoming a cancer cell that allow them to survive, proliferate and disseminate. The renin-angiotensin system (RAS) was first discovered and extensively studied in the physiological regulation of systemic arterial pressure. RAS signalling increases cell proliferation in malignancy by directly affecting tumour and stromal cells and by indirectly modulating the growth of vascular cells during angiogenesis. We aim to describe and give a general view of how the RAS is involved in several hallmarks of cancer and how this could open a window to several interesting treatments.
癌症的特征被描述为细胞在成为癌细胞的多步骤发展过程中必须获得的独特且互补的能力，这些能力使它们能够存活、增殖和扩散。肾素-血管紧张素系统（RAS）最初是在全身动脉压的生理调节中被发现并广泛研究的。RAS信号传导通过直接影响肿瘤细胞和基质细胞以及在血管生成过程中间接调节血管细胞的生长，从而增加恶性肿瘤中的细胞增殖。我们旨在描述并概述RAS如何参与癌症的多个特征，以及这如何为一些有趣的治疗方法打开一扇窗。
