斋月禁食对2型糖尿病患者血糖控制的影响。
The impact of fasting during Ramadan on the glycemic control of patients with type 2 diabetes mellitus.
作者信息
Sahin S B, Ayaz T, Ozyurt N, Ilkkilic K, Kirvar A, Sezgin H
机构信息
Department of Endocrinology and Metabolism Disease, Recep Tayyip Erdogan University, Rize, Turkey.
出版信息
Exp Clin Endocrinol Diabetes. 2013 Oct;121(9):531-4. doi: 10.1055/s-0033-1347247. Epub 2013 Aug 9.
BACKGROUND
Millions of Muslims fast from dawn until dusk during the annual Islamic holy month of Ramadan. Most of the studies evaluating biochemical changes in diabetic patients during Ramadan showed little changes in the glycemic control. In this study, our aim was to assess the impact of fasting during Ramadan on glycemic control in patients with type 2 diabetes.
METHODS AND DESIGN
We examined 122 patients with type 2 diabetes (82 female, 40 male, age 56.93 ± 9.57 years) before and after the Ramadan. 66.4% of the patients were treated with oral antidiabetic (OAD) alone, 6.5% with a combination of insulin plus OAD and 19.7% with insulin alone. 88 of 122 patients fasted during Ramadan (26.98 ± 5.93 days). Weight, body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose (FPG), postprandial glucose (PPG), fructosamine, HbA1c, fasting insulin and lipid parameters were measured.
RESULTS
The frequencies of both severe hyperglycemia and hypoglycemia were higher in the fasting group, but the difference was not significant (p=0.18). Weight, BMI, waist circumference, blood pressure, FPG (143.38 ± 52.04 vs. 139.31 ± 43.47 mg/dl) PPG (213.40 ± 98.56 vs. 215.66+109.31 mg/dl), fructosamine (314.18 ± 75.40 vs. 314.49 ± 68.36 µmol/l), HbA1c (6.33 ± 0.98 vs. 6.22 ± 0.92%) and fasting insulin (12.61 ± 8.94 vs. 10.51 ± 6.26 µU/ml) were unchanged in patients who fasted during Ramadan. Microalbuminuria significantly decreased during Ramadan (132.85 ± 197.11 vs. 45.03 ± 73.11 mg/dl).
CONCLUSIONS
In this study, we concluded that fasting during Ramadan did not worsen the glycemic control of patients with type 2 diabetes.
背景
在每年的伊斯兰斋月期间，数百万穆斯林从黎明到黄昏禁食。大多数评估糖尿病患者在斋月期间生化变化的研究表明，血糖控制变化不大。在本研究中，我们的目的是评估斋月期间禁食对2型糖尿病患者血糖控制的影响。
方法与设计
我们在斋月前后检查了122例2型糖尿病患者（82例女性，40例男性，年龄56.93±9.57岁）。66.4%的患者仅接受口服降糖药（OAD）治疗，6.5%的患者接受胰岛素加OAD联合治疗，19.7%的患者仅接受胰岛素治疗。122例患者中有88例在斋月期间禁食（26.98±5.93天）。测量了体重、体重指数（BMI）、腰围、血压、空腹血糖（FPG）、餐后血糖（PPG）、果糖胺、糖化血红蛋白（HbA1c）、空腹胰岛素和血脂参数。
结果
禁食组严重高血糖和低血糖的发生率均较高，但差异无统计学意义（p=0.18）。斋月期间禁食的患者体重、BMI、腰围、血压、FPG（143.38±52.04 vs.139.31±43.47mg/dl）、PPG（213.40±98.56 vs.215.66+109.31mg/dl）、果糖胺（314.18±75.40 vs.314.49±68.36µmol/l）、HbA1c（6.33±0.98 vs.6.22±0.92%）和空腹胰岛素（12.61±8.94 vs.10.51±6.26µU/ml）均无变化。斋月期间微量白蛋白尿显著降低（132.85±197.11 vs.45.03±73.11mg/dl）。
结论
在本研究中，我们得出结论，斋月期间禁食不会使2型糖尿病患者的血糖控制恶化。
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