Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida.
Am J Hypertens. 2013 Dec;26(12):1389-97. doi: 10.1093/ajh/hpt131. Epub 2013 Aug 9.
Although increased sympathetic nervous system (SNS) activity is commonly associated with major depressive disorder (MDD) and cardiovascular disease (CVD), a biomarker linking these two entities remains elusive. We therefore evaluated the relationship between depressive symptoms and cardiovascular modulation by heart rate variability (HRV), brachial blood pressure (BP), ambulatory BP (ABP), and low frequency component of systolic BP variability (LFSBP), a surrogate of sympathetic vasomotor tone. We hypothesized that LFSBP would be the strongest predictor of depressive symptoms compared with HRV and BP measurements.
Eighty young healthy female subjects (20.51 ± 2.82 years) were evaluated for depressive symptoms using the Center for Epidemiologic Studies Depression Scale (CES-D). Data collection was conducted after a 10-minute resting period. Beat-to-beat BPs were recorded for 5-minute at baseline (BASE) followed by a 3-minute cold pressor test (CPT). ABP was obtained for 24 hours.
Hierarchical multiple regression analyses indicated that LFSBP at BASE was a stronger predictor of CES-D variance than BP and HRV indices, with LFSBP uniquely accounting for 8.1% of variance in CES-D scores during laboratory beat-by-beat BP assessments and 44.7% in ABP assessments. Individuals with acute depression scores (n = 12; CES-D ≥ 16) had significantly higher (P < 0.001) mean LFSBP values (6.66 ± 2.54 mm Hg(2)) than the remaining sample (3.32 ± 2.2 mm Hg(2)), whereas no other significant differences were detected in any of the other cardiovascular variables. Cardiovascular responses to CPT did not predict CES-D scores.
These findings suggest that LFSBP could be a biomarker of neurovascular functioning with potential clinical implications for understanding the interaction between MDD and CVD.
尽管交感神经系统（SNS）活动增加通常与重度抑郁症（MDD）和心血管疾病（CVD）相关，但将这两者联系起来的生物标志物仍然难以捉摸。因此，我们评估了抑郁症状与心率变异性（HRV）、肱动脉血压（BP）、动态血压（ABP）和收缩压变异的低频成分（LFSBP）之间的关系，LFSBP 是交感血管运动张力的替代物。我们假设与 HRV 和 BP 测量相比，LFSBP 是预测抑郁症状的最强指标。
对 80 名年轻健康的女性受试者（20.51 ± 2.82 岁）进行了抑郁症状评估，采用流行病学研究中心抑郁量表（CES-D）进行评估。数据采集是在 10 分钟的休息时间后进行的。在基线（BASE）记录了 5 分钟的逐搏 BP，然后进行 3 分钟的冷加压试验（CPT）。24 小时内获得 ABP。
分层多元回归分析表明，BASE 时的 LFSBP 是 CES-D 方差的更强预测指标，比 BP 和 HRV 指数更为重要，LFSBP 可单独解释实验室逐搏 BP 评估中 CES-D 评分的 8.1%和 ABP 评估中的 44.7%的方差。具有急性抑郁评分（n = 12；CES-D ≥ 16）的个体的 LFSBP 值（6.66 ± 2.54 mm Hg（2））明显高于其余样本（3.32 ± 2.2 mm Hg（2））（P < 0.001），而其他心血管变量则没有显著差异。CPT 对 CES-D 评分无预测作用。
这些发现表明，LFSBP 可能是神经血管功能的生物标志物，对理解 MDD 和 CVD 之间的相互作用具有潜在的临床意义。
