Department of Psychology, Indiana University–Purdue University Indianapolis, IN 46202, USA.
Int J Psychophysiol. 2011 Sep;81(3):317-23. doi: 10.1016/j.ijpsycho.2011.07.018. Epub 2011 Aug 16.
Depression and hostility have been separately related to indicators of sympathetic hyperactivation and parasympathetic hypoactivation. We examined the associations of depressive symptoms, hostility, and their interaction with pre-ejection period (PEP) and high frequency heart rate variability (HRV), specific indices of sympathetic and parasympathetic cardiac control, respectively. Healthy, young adults (N=120) completed questionnaires assessing depressive symptoms and hostility and underwent autonomic testing. Although main effects were not observed, a depressive symptoms×hostility interaction was detected for PEP (β=.25, p=.01). Simple slope analyses revealed that hostility was negatively related to PEP among individuals with low depressive symptoms but was not associated with PEP among those with mild-to-moderate depressive symptoms. No interaction effect was detected for high frequency HRV. Our findings suggest that depressive symptoms may moderate the link between hostility and sympathetic activation such that hostility is accompanied by sympathetic hyperactivation only when depressive symptoms are minimal.
抑郁和敌意分别与交感神经兴奋和副交感神经抑制的指标有关。我们分别考察了抑郁症状、敌意及其相互作用与射血前期（PEP）和高频心率变异性（HRV）的关系，PEP 和 HRV 是交感和副交感心脏控制的特定指标。健康的年轻成年人（N=120）完成了评估抑郁症状和敌意的问卷，并进行了自主神经测试。虽然没有观察到主要效应，但检测到 PEP 上存在抑郁症状×敌意的交互作用（β=.25，p=.01）。简单斜率分析显示，在抑郁症状较轻的个体中，敌意与 PEP 呈负相关，但在轻度至中度抑郁症状的个体中，敌意与 PEP 无关。高频 HRV 没有检测到交互作用效应。我们的研究结果表明，抑郁症状可能会调节敌意与交感神经兴奋之间的联系，使得只有在抑郁症状最轻微时，敌意才会伴随着交感神经兴奋。
