Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.
J Immunol. 2013 Sep 15;191(6):3128-38. doi: 10.4049/jimmunol.1301163. Epub 2013 Aug 9.
Long-lived plasma cells (LLPCs) that maintain humoral immunity to previously encountered Ags occupy a compartment in the bone marrow (BM). The rules and mechanisms by which cells enter (and leave) this compartment are poorly understood. We looked at what happens to the LLPC compartment and to plasma cell lifespan in general, in situations in which Ag stimulation and/or inflammation persist. We find that chronic Ag supply causes the generation of short-lived plasma cells in the local lymphoid organ, at the expense of any LLPC production. Furthermore, we find that inflammation caused by infection (mediated via TNF-α) causes a dramatic mobilization of LLPCs from the BM, with a concomitant reduction in circulating Ab levels against previously immunized Ags. These data are discussed in the context of the capacity of the BM LLPC compartment and competition for entry to it.
长期存活的浆细胞（LLPCs）能够维持对先前遇到的抗原的体液免疫，它们占据骨髓（BM）中的一个隔室。细胞进入（和离开）这个隔室的规则和机制还不太清楚。我们研究了当抗原刺激和/或炎症持续存在时，LLPC 隔室以及浆细胞寿命通常会发生什么变化。我们发现，慢性抗原供应导致局部淋巴器官中产生短期存活的浆细胞，而牺牲了任何 LLPC 的产生。此外，我们发现感染引起的炎症（通过 TNF-α介导）导致 LLPC 从 BM 中大量动员，同时循环中针对先前免疫的抗原的 Ab 水平降低。这些数据在 BM LLPC 隔室的能力和进入该隔室的竞争的背景下进行了讨论。
