重型β地中海贫血合并自身免疫性溶血性贫血患者孕期的环孢素治疗：一例病例报告及文献综述
Cyclosporine therapy during pregnancy in a patient with β-thalassemia major and autoimmune haemolytic anemia: a case report and review of the literature.
作者信息
Agapidou A, Vlachaki E, Theodoridis T, Economou M, Perifanis V
机构信息
Thalasemia Unit, Hippokratio General Hospital, Thessaloniki, Greece.
出版信息
Hippokratia. 2013 Jan;17(1):85-7.
Abstract
Recent advances in the management of hemoglobinopathies offer an improved potential for safe pregnancy with favourable outcome in patients with β-thalassemia major. Autoimmune diseases that are common in women at reproductive age might be fulminant and hardly manageable in pregnant women with thalassemia. Thus immunosuppressant drugs like cyclosporine A could be necessary in order to maintain good maternal and foetal health. We present a case report of a 35-year-old woman with β-thalassemia major, splenectomy, autoimmune hemolytic anemia and insulin treated diabetes mellitus who was treated with cyclosporine A during her pregnancy, and delivered a healthy male infant. First line therapy with steroids was ineffective, due to deregulation of diabetes mellitus.
摘要
血红蛋白病管理方面的最新进展为重型β地中海贫血患者实现安全妊娠并获得良好结局提供了更高的可能性。自身免疫性疾病在育龄女性中很常见，对于患有地中海贫血的孕妇来说可能会很严重且难以控制。因此，可能需要使用环孢素A等免疫抑制药物来维持母婴的良好健康状况。我们报告一例35岁患有重型β地中海贫血、行脾切除术、自身免疫性溶血性贫血且接受胰岛素治疗的糖尿病的女性病例，她在孕期接受了环孢素A治疗，并产下一名健康男婴。由于糖尿病失控，一线类固醇治疗无效。
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