Dubois Declercq Sarah, Pouliot Roxane
Centre LOEX de l'Université Laval, Génie Tissulaire et Régénération, LOEX-Centre de Recherche FRSQ du CHU, Aile-R, 1401 18e Rue, Québec, QC G1J 1Z4, Canada.
ScientificWorldJournal. 2013 Jul 1;2013:980419. doi: 10.1155/2013/980419. Print 2013.
Psoriasis is a chronic, proliferative, and inflammatory skin disease affecting 2-3% of the population and is characterized by red plaques with white scales. Psoriasis is a disease that can affect many aspects of professional and social life. Currently, several treatments are available to help control psoriasis such as methotrexate, ciclosporin, and oral retinoids. However, the available treatments are only able to relieve the symptoms and lives of individuals. The discovery of new immunological factors and a better understanding of psoriasis have turned to the use of immunological pathways and could develop new biological drugs against specific immunological elements that cause psoriasis. Biological drugs are less toxic to the body and more effective than traditional therapies. Thus, they should improve the quality of life of patients with psoriasis. This review describes new psoriasis treatments, which are on the market or currently in clinical trials that are being used to treat moderate-to-severe plaque psoriasis. In addition, this paper describes the characteristics and mechanisms in detail. In general, biological drugs are well tolerated and appear to be an effective alternative to conventional therapies. However, their effectiveness and long-term side effects need to be further researched.
银屑病是一种慢性、增殖性炎症性皮肤病，影响着2%-3%的人口，其特征为带有白色鳞屑的红色斑块。银屑病是一种会影响职业和社会生活诸多方面的疾病。目前，有多种治疗方法可用于帮助控制银屑病，如甲氨蝶呤、环孢素和口服类维生素A。然而，现有的治疗方法只能缓解症状并改善个体生活。新免疫因子的发现以及对银屑病更深入的了解促使人们转向利用免疫途径，并研发针对引发银屑病的特定免疫元件的新型生物药物。生物药物对身体毒性较小，且比传统疗法更有效。因此，它们应能改善银屑病患者的生活质量。本综述介绍了已上市或目前正在进行临床试验的用于治疗中重度斑块状银屑病的新型银屑病治疗方法。此外，本文还详细描述了其特点和作用机制。总体而言，生物药物耐受性良好，似乎是传统疗法的有效替代方案。然而，它们的有效性和长期副作用仍需进一步研究。
