Rui Biyu, Guo Shangchun, Zeng Bingfang, Wang Jingwu, Chen Xin
Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233;
Exp Ther Med. 2013 Jul;6(1):22-28. doi: 10.3892/etm.2013.1110. Epub 2013 May 13.
This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel clamp. Electrical stimulators were implanted in twenty of the rats (the implantation group), while the remaining twenty rats were assigned to the control group. At three and six weeks following the surgery, the sciatic nerve function index (SFI) and the motor nerve conduction velocity (MCV) were demonstrated to be significantly higher in the implantation group compared with the control group (P<0.05). Histological analysis, using hematoxylin and eosin (H&E) staining, showed the typical pathological atrophy, and an assessment of the nerve that had been crushed revealed distal axonal breakdown in the control group. These results suggest that the implantable electrical stimulator was effective, and was suitable for implantation in a Sprague-Dawley rat model.
本研究使用坐骨神经损伤动物模型，通过行为学、电生理学和组织学评估，对一种可植入式电刺激器进行了评价。该研究使用了40只Sprague-Dawley大鼠，用微血管夹夹闭其右侧坐骨神经。将电刺激器植入20只大鼠（植入组），其余20只大鼠作为对照组。术后3周和6周时，与对照组相比，植入组的坐骨神经功能指数（SFI）和运动神经传导速度（MCV）显著更高（P<0.05）。苏木精-伊红（H&E）染色的组织学分析显示出典型的病理性萎缩，对夹闭神经的评估显示对照组存在远端轴突断裂。这些结果表明，该可植入式电刺激器是有效的，适用于Sprague-Dawley大鼠模型。
