Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania.
PLoS One. 2013 Aug 6;8(8):e71530. doi: 10.1371/journal.pone.0071530. Print 2013.
Although several studies have been conducted regarding Kaposi sarcoma (KS), its histogenesis still remains to be elucidated. The aim of our study was to analyze the immunophenotype of Kaposi sarcoma and to present a hypothesis about the histogenesis of this tumor, based on a case series and a review of relevant literature.
In 15 cases of KSs diagnosed during 2000-2011, the clinicopathological features were correlated with the immunoexpression of c-Kit, SMA, CD34, CD31, vascular endothelial growth factor (VEGF), COX-2, c-KIT, smooth muscle antigen (SMA), and stem cell surface marker CD105.
Both CD105 and c-KIT rate of the spindle-shaped tumor cell positivity increased in parallel to the pathological stage. All cases displayed CD105 and weak c-KIT positivity in the endothelial cells. SMA, VEGF, and COX-2 were focally expressed in all cases. CD34 marked both endothelium and spindle-shaped tumor cells. No c-KIT expression was noticed in KS of the internal organs.
KS seems to be a variant of myofibroblastic tumors that originates from the viral modified pluripotent mesenchymal cells of the connective tissue transformed in spindle-shaped KS cells, followed by a mesenchymal-endothelial transition and a myofibroblastic-like differentiation. This paper mailnly showed that KS cannot be considered a pure vascular tumor.
尽管已经有几项关于卡波西肉瘤（KS）的研究，但它的组织发生仍有待阐明。我们的研究目的是分析卡波西肉瘤的免疫表型，并基于一系列病例和相关文献的复习，提出该肿瘤的组织发生假说。
在 2000-2011 年间诊断的 15 例 KS 病例中，将临床病理特征与 c-Kit、SMA、CD34、CD31、血管内皮生长因子（VEGF）、COX-2、c-KIT、平滑肌抗原（SMA）和干细胞表面标志物 CD105 的免疫表达进行了相关性分析。
梭形肿瘤细胞的 CD105 和 c-KIT 阳性率均随病理分期的增加而平行增加。所有病例的内皮细胞均显示 CD105 和弱阳性 c-KIT 阳性。所有病例 SMA、VEGF 和 COX-2 均呈局灶性表达。CD34 标记内皮细胞和梭形肿瘤细胞。内脏 KS 中未见 c-KIT 表达。
KS 似乎是一种肌纤维母细胞瘤的变体，它起源于结缔组织中被病毒修饰的多能间充质细胞，转化为梭形 KS 细胞，随后发生间充质-内皮转化和肌纤维母细胞样分化。本文主要表明 KS 不能被认为是一种纯血管肿瘤。
