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癫痫性脑病的生酮饮食

Ketogenic diet in epileptic encephalopathies.

作者信息

Sharma Suvasini, Tripathi Manjari

机构信息

Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi 110001, India.

出版信息

Epilepsy Res Treat. 2013;2013:652052. doi: 10.1155/2013/652052. Epub 2013 Jul 10.

DOI:10.1155/2013/652052
PMID:23936641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3723152/
Abstract

The ketogenic diet is a medically supervised high-fat, low-carbohydrate diet that has been found useful in patients with refractory epilepsy. It has been shown to be effective in treating multiple seizure types and epilepsy syndromes. In this paper, we review the use of the ketogenic diet in epileptic encephalopathies such as Ohtahara syndrome, West syndrome, Dravet syndrome, epilepsy with myoclonic atonic seizures, and Lennox-Gastaut syndrome.

摘要

生酮饮食是一种在医学监督下的高脂肪、低碳水化合物饮食,已被发现对难治性癫痫患者有用。它已被证明对治疗多种发作类型和癫痫综合征有效。在本文中,我们回顾了生酮饮食在诸如大田原综合征、韦斯特综合征、德雷维特综合征、肌阵挛失张力发作癫痫和伦诺克斯 - 加斯东综合征等癫痫性脑病中的应用。

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Ketogenic diet in epileptic encephalopathies.癫痫性脑病的生酮饮食
Epilepsy Res Treat. 2013;2013:652052. doi: 10.1155/2013/652052. Epub 2013 Jul 10.
2
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3
Epileptic encephalopathies: an overview.癫痫性脑病:概述
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Current understanding and neurobiology of epileptic encephalopathies.癫痫性脑病的当前认识与神经生物学
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The ketogenic diet can be used successfully in combination with corticosteroids for epileptic encephalopathies.生酮饮食可与皮质类固醇联合成功用于治疗癫痫性脑病。
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CNS Drugs. 2021 Mar;35(3):265-281. doi: 10.1007/s40263-021-00807-y. Epub 2021 Mar 22.
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Management of seizures in Lennox-Gastaut syndrome.Lennox-Gastaut 综合征的癫痫发作管理。
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Long-term outcome of developmental and epileptic encephalopathies.发育性和癫痫性脑病的长期预后。
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Ketogenic diet in patients with Lennox-Gastaut syndrome.生酮饮食用于伦诺克斯-加斯托综合征患者
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Ketogenic Diet in the Treatment of Epilepsy.生酮饮食治疗癫痫。
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Metabolic Derangement in Pediatric Patient with Obesity: The Role of Ketogenic Diet as Therapeutic Tool.肥胖症儿科患者的代谢紊乱:生酮饮食作为治疗工具的作用。
Nutrients. 2021 Aug 16;13(8):2805. doi: 10.3390/nu13082805.
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Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management.生酮饮食在癫痫管理中的作用的当前观点
Neuropsychiatr Dis Treat. 2019 Nov 25;15:3273-3285. doi: 10.2147/NDT.S201862. eCollection 2019.
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Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations.超长链脂肪酸的新型细胞功能:来自ELOVL4突变的见解
Front Cell Neurosci. 2019 Sep 20;13:428. doi: 10.3389/fncel.2019.00428. eCollection 2019.
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Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet.生酮饮食刺激下(2E)-4-羟基-2-壬烯醛通过ω-和ω-1-氧化途径的分解代谢。
J Biol Chem. 2014 Nov 14;289(46):32327-32338. doi: 10.1074/jbc.M114.602458. Epub 2014 Oct 1.

本文引用的文献

1
Use of the modified Atkins diet for treatment of refractory childhood epilepsy: a randomized controlled trial.改良阿特金斯饮食治疗耐药性儿童癫痫:一项随机对照试验。
Epilepsia. 2013 Mar;54(3):481-6. doi: 10.1111/epi.12069. Epub 2013 Jan 7.
2
Efficacy of the ketogenic diet in Lennox-Gastaut syndrome: a retrospective review of one institution's experience and summary of the literature.生酮饮食治疗 Lennox-Gastaut 综合征的疗效:一家机构的回顾性研究及文献综述
Dev Med Child Neurol. 2012 May;54(5):464-8. doi: 10.1111/j.1469-8749.2012.04233.x. Epub 2012 Mar 22.
3
Is the ketogenic diet effective in specific epilepsy syndromes?生酮饮食在特定癫痫综合征中是否有效?
Epilepsy Res. 2012 Jul;100(3):252-7. doi: 10.1016/j.eplepsyres.2012.01.015. Epub 2012 Mar 15.
4
Efficacy of the ketogenic diet: which epilepsies respond?生酮饮食的疗效:哪些癫痫发作有反应?
Epilepsia. 2012 Mar;53(3):e55-9. doi: 10.1111/j.1528-1167.2011.03394.x. Epub 2012 Feb 6.
5
Ketogenic diet in early myoclonic encephalopathy due to non ketotic hyperglycinemia.非酮性高甘氨酸血症所致早发性肌阵挛性脑病的生酮饮食治疗。
Eur J Paediatr Neurol. 2012 Sep;16(5):509-13. doi: 10.1016/j.ejpn.2011.12.015. Epub 2012 Jan 18.
6
A case of malignant migrating partial seizures in infancy as a continuum of infantile epileptic encephalopathy.一例婴儿期恶性迁移性部分性癫痫,为婴儿癫痫性脑病的一种连续表现。
Brain Dev. 2012 Oct;34(9):768-72. doi: 10.1016/j.braindev.2011.11.011. Epub 2011 Dec 24.
7
Use of the modified Atkins diet in infantile spasms refractory to first-line treatment.改良型阿特金斯饮食用于治疗一线治疗抵抗的婴儿痉挛症。
Seizure. 2012 Jan;21(1):45-8. doi: 10.1016/j.seizure.2011.08.009. Epub 2011 Sep 14.
8
Myoclonic astatic epilepsy and the use of the ketogenic diet.肌阵挛失张力癫痫与生酮饮食的应用。
Epilepsy Res. 2012 Jul;100(3):258-60. doi: 10.1016/j.eplepsyres.2011.04.009. Epub 2011 May 31.
9
Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: a prospective pilot study.生酮饮食也有益于接受司替戊醇治疗的 Dravet 综合征患者:一项前瞻性初步研究。
Epilepsia. 2011 Jul;52(7):e54-7. doi: 10.1111/j.1528-1167.2011.03107.x. Epub 2011 May 13.
10
Glucose transporter 1 deficiency as a treatable cause of myoclonic astatic epilepsy.葡萄糖转运体1缺乏症是肌阵挛性失张力癫痫的一个可治疗病因。
Arch Neurol. 2011 Sep;68(9):1152-5. doi: 10.1001/archneurol.2011.102. Epub 2011 May 9.