Provenzano Joel D, Kuebler J Phillip
Riverside Methodist Hospital, Columbus, OH, USA ; Pulmonary Critical Care Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Case Rep Hematol. 2013;2013:709164. doi: 10.1155/2013/709164. Epub 2013 Jul 10.
Myeloproliferative disorders are variable disorders, based on the genetic abnormality present and the cell line progenitors that are affected. In this case, we discuss a novel gene translocation in the subset of PDGFRB mutations, first seen with prominent hyperbasophilia. This case demonstrates the possibility for lower therapeutic doses of imatinib mesylate than previously reported, in order to control leukocyte counts and reverse the genetic mutation.
骨髓增殖性疾病是基于存在的基因异常和受影响的细胞系祖细胞而表现各异的疾病。在本病例中，我们讨论了血小板衍生生长因子受体β（PDGFRB）突变亚组中的一种新型基因易位，首次发现时伴有显著的嗜碱性粒细胞增多。该病例表明，与先前报道相比，使用更低治疗剂量的甲磺酸伊马替尼来控制白细胞计数并逆转基因突变是有可能的。
