Integrative Rehabilitation Medicine Department, National Rehabilitation Hospital, National Research Center for Rehabilitation Technical Aids, Beijing, China.
Biomed Res Int. 2013;2013:734326. doi: 10.1155/2013/734326. Epub 2013 Jul 10.
The insula is believed to be associated with touch-evoked effects. In this work, functional MRI was applied to investigate the network model of insula function when 20 normal subjects received tactile stimulation over segregated areas. Data analysis was performed with SPM8 and Conn toolbox. Activations in the contralateral posterior insula were consistently revealed for all stimulation areas, with the overlap located in area Ig2. The area Ig2 was then used as the seed to estimate the insula-associated network. The right insula, left superior parietal lobule, left superior temporal gyrus, and left inferior parietal cortex showed significant functional connectivity with the seed region for all stimulation conditions. Connectivity maps of most stimulation conditions were mainly distributed in the bilateral insula, inferior parietal cortex, and secondary somatosensory cortex. Post hoc ROI-to-ROI analysis and graph theoretical analysis showed that there were higher correlations between the left insula and the right insula, left inferior parietal cortex and right OP1 for all networks and that the global efficiency was more sensitive than the local efficiency to detect differences between notes in a network. These results suggest that the posterior insula serves as a hub to functionally connect other regions in the detected network and may integrate information from these regions.
脑岛被认为与触觉诱发的效应有关。在这项工作中，应用功能磁共振成像(fMRI)研究 20 名正常受试者在接受分隔区域的触觉刺激时脑岛功能的网络模型。数据分析采用 SPM8 和 Conn 工具箱进行。对于所有的刺激区域，都一致显示出对侧后岛的激活，重叠区域位于 Ig2 区。然后，将 Ig2 区作为种子来估计与脑岛相关的网络。在所有刺激条件下，右侧脑岛、左侧顶叶上回、左侧颞上回和左侧顶下小叶与种子区域显示出显著的功能连接。大多数刺激条件的连通图主要分布在双侧脑岛、顶下小叶和次级体感皮层。事后 ROI-ROI 分析和图论分析表明，在所有网络中，左侧脑岛与右侧脑岛、左侧顶下小叶与右侧 OP1 之间的相关性更高，全局效率比局部效率更能敏感地检测到网络中各节点之间的差异。这些结果表明，后岛作为一个枢纽，将功能连接到检测到的网络中的其他区域，并可能整合来自这些区域的信息。
