He Jian, Wu Ping, Wu Surina, Yu Su Fu, Li Mi Ri Ka Mi, Liao Lingfeng, Quan Huatao, Zhang Shuai, Tang Yaoyun
Department of Otorhinolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 May;27(10):473-4.
To observed the prevention efficacy of secretory otitis media after radiation therapy by the Myrtol Standardized Enteric Coated Soft Capsules.
Sixty patients with nasopharyngeal carcinoma who Diagnosis without secretory otitis media before radiation therapy were divided into experimental group and control group, 30 cases in each group. After the start of radiation therapy ,the experimental group patients oral the Myrtol Standardized Enteric Coated Soft Capsules, each 0.3 g, 3 times a day, 7 days a course of treatment, oral the medication three months, the patients in the control group received no treatment. 3 months and 6 months after the end of radiation therapy, whether there is a difference comparison of experimental group and the control group in symptoms, signs, pure tone audiometry and tympanogram change.
Seventeen patients (18 ears) (56.67%, 17/30) in the control group were suffering from secretory otitis media, 7 patients (7 ears) (23.33%, 7/30) in the experimental group were suffering from secretory otitis media. The difference between the two groups was statistically significant (P < 0.01). 17 patients (17 ears) in the control group and 7 patients (7 ears) in the experimental group were suffering from tinnitus. 20 patients(20 ears) in the control group and 9 patients (10 ears) in the experimental group have ear choking feeling. The difference between the two groups was statistically significant (P < 0.01). The air conduction hearing threshold of the experimental group before radiation therapy is (7.5 +/- 2.0) dB HL and the air conduction hearing threshold of the control group patients is (8.3 +/- 4.0) dB HL. The difference between the two groups was not statistically significant (P > 0.05). 3 months after radiation therapy,the gas conductive hearing threshold of the experimental group is (25.6 +/- 3.0) dB HL, but the data in the control group is (40.7 +/- 5.0) dB HL. The difference between the two groups was statistically significant (P < 0.01).
Patients with nasopharyngeal carcinoma oral the the Myrtol Standardized Enteric Coated Soft Capsules before radiation therapy can effectively reduce the incidence of secretory otitis media after radiotherapy, it can prevent the occurrence of secretory otitis media.
观察标准桃金娘油肠溶软胶囊对鼻咽癌放疗后分泌性中耳炎的预防效果。
选取60例放疗前诊断无分泌性中耳炎的鼻咽癌患者，分为实验组和对照组，每组30例。放疗开始后，实验组患者口服标准桃金娘油肠溶软胶囊，每次0.3g，每日3次，7天为一个疗程，口服3个月，对照组患者不接受治疗。放疗结束后3个月和6个月，比较实验组和对照组在症状、体征、纯音听力测试及鼓室图变化方面是否存在差异。
对照组有17例患者（18耳）（56.67%，17/30）发生分泌性中耳炎，实验组有7例患者（7耳）（23.33%，7/30）发生分泌性中耳炎。两组差异有统计学意义（P<0.01）。对照组有17例患者（17耳）、实验组有7例患者（7耳）出现耳鸣。对照组有20例患者（20耳）、实验组有9例患者（10耳）有耳闷感。两组差异有统计学意义（P<0.01）。放疗前实验组气导听阈为（7.5±2.0）dB HL，对照组患者气导听阈为（8.3±4.0）dB HL。两组差异无统计学意义（P>0.05）。放疗后3个月，实验组气导听阈为（25.6±3.0）dB HL，而对照组数据为（40.7±5.0）dB HL。两组差异有统计学意义（P<0.01）。
鼻咽癌患者放疗前口服标准桃金娘油肠溶软胶囊可有效降低放疗后分泌性中耳炎的发生率，能预防分泌性中耳炎的发生。
