Interleukin-27 rs153109 polymorphism and the risk for immune thrombocytopenia.

The aim of the present study was to investigate the association of single nucleotide polymorphisms (SNP) of the interleukin-27 (IL-27) genes with the risk for immune thrombocytopenia (ITP). In this case-control study, the genotyping of IL-27 rs153109 polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In ITP patients, the frequencies of GG, GA and AA genotypes, and G and A alleles were 9.7%, 58.5%, 31.8%, 38.9% and 61.1%, respectively. There was no significant difference in genotype and alleles distribution between the ITP patient and the healthy controls (p = 0.68 and 0.80, respectively). Similar results were found between the two groups when stratified by the age and disease course including non-chronic adult, chronic adult, non-chronic childhood, and chronic childhood. In conclusion, the IL-27 polymorphism may not be involved in susceptibility to ITP in a Chinese population.