Nogami Yuya, Tsuji Kousuke, Banno Kouji, Umene Kiyoko, Katakura Satomi, Kisu Iori, Tominaga Eiichiro, Aoki Daisuke
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
J Obstet Gynaecol Res. 2014 Jan;40(1):250-4. doi: 10.1111/jog.12126. Epub 2013 Aug 12.
Streptococcal toxic shock syndrome (STSS) is a severe infectious disease caused by group A hemolytic streptococcus (Streptococcus pyogenes). This condition is a serious disease that involves rapidly progressive septic shock. We experienced a case of STSS caused by primary peritonitis during treatment with paclitaxel and cisplatin (TP therapy) as postoperative chemotherapy for cervical cancer. STSS mostly develops after extremity pain, but initial influenza-like symptoms of fever, chill, myalgia and gastrointestinal symptoms may also occur. TP therapy is used to treat many cancers, including gynecological cancer, but may cause adverse reactions of neuropathy and nephrotoxicity and sometimes fever, arthralgia, myalgia, abdominal pain and general malaise. The case reported here indicates that development of STSS can be delayed after chemotherapy and that primary STSS symptoms may be overlooked because they may be viewed as adverse reactions to chemotherapy. To our knowledge, this is the first report of a case of STSS during chemotherapy.
链球菌中毒性休克综合征（STSS）是一种由A组溶血性链球菌（化脓性链球菌）引起的严重传染病。这种病症是一种严重疾病，涉及迅速进展的感染性休克。我们遇到了一例在紫杉醇和顺铂（TP疗法）作为宫颈癌术后化疗期间由原发性腹膜炎引起的STSS病例。STSS大多在肢体疼痛后发生，但也可能出现发热、寒战、肌痛和胃肠道症状等初始类似流感的症状。TP疗法用于治疗包括妇科癌症在内的多种癌症，但可能会引起神经病变和肾毒性等不良反应，有时还会出现发热、关节痛、肌痛、腹痛和全身不适。此处报告的病例表明，化疗后STSS的发生可能会延迟，并且原发性STSS症状可能会被忽视，因为它们可能被视为化疗的不良反应。据我们所知，这是化疗期间发生STSS病例的首例报告。
